Biphasic changes in hippocampal granule cells after traumatic brain injury

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2025-04-26 DOI:10.1016/j.expneurol.2025.115281

Joanna Danielewicz , Nerea Llamosas , Irene Durá , Danillo Barros de Souza , Serafim Rodrigues , Juan Manuel Encinas-Pérez , Diego Martin Mateos

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引用次数: 0

Abstract

Traumatic brain injury (TBI) leads to a wide range of long-lasting physical and cognitive impairments. Changes in neuronal excitability and synaptic functions in the hippocampus have been proposed to underlie cognitive alterations. The dentate gyrus (DG) acts as a “gatekeeper” of hippocampal information processing and as a filter of excessive or aberrant input activity. In this study, we investigated the effects of controlled cortical impact, a model of TBI, on the excitability of granule cells (GCs) and spontaneous excitatory postsynaptic currents (sEPSCs) in the DG at three time points, 3 days, 15 days and 4 months after the injury in male and female mice. Our results indicate that changes in the short term are related to intrinsic properties, while changes in the long term are more related to input and synaptic activity, in agreement with the notion that TBI-related pathology courses with an acute phase and a later long-term secondary phase. A biphasic response, a reduction in the shorter term and an increase in the long term, was found in TBI neurons in the frequency of sEPSCs. These changes correlated with a loss of complexity in the pattern of the synaptic input, an alteration that could therefore play a role in the chronic and recurrent TBI-associated hyperexcitation.

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外伤性脑损伤后海马颗粒细胞的双相变化

外伤性脑损伤（TBI）会导致一系列长期的身体和认知损伤。海马神经元兴奋性和突触功能的变化被认为是认知改变的基础。齿状回（DG）作为海马体信息处理的“守门人”，并作为过度或异常输入活动的过滤器。在本研究中，我们研究了脑外伤模型——控制性皮质冲击在损伤后3天、15天和4个月三个时间点对雄性和雌性小鼠DG中颗粒细胞（GCs）兴奋性和自发兴奋性突触后电流（sEPSCs）的影响。我们的研究结果表明，短期的变化与内在特性有关，而长期的变化更多地与输入和突触活动有关，这与tbi相关的病理过程具有急性期和后来的长期继发性的概念一致。在TBI神经元中，sEPSCs的频率出现了短期减少和长期增加的双相反应。这些变化与突触输入模式复杂性的丧失相关，因此这种改变可能在慢性和复发性脑外伤相关的过度兴奋中发挥作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.