Diagnostic value of cardiac magnetic resonance imaging-based left atrial strain analysis for identifying cardiac diseases with overlapping phyotype

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-05-01 DOI:10.1016/j.ejrad.2025.112153

Constantin Reichardt , Maximilian Moos , Tilman Emrich , Karl-Friedrich Kreitner , Lukas Müller , Lukas Hobohm , Tobias Bäuerle , Akos Varga-Szemes , Moritz C. Halfmann

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引用次数: 0

Abstract

Background

The main objective of this study was to compare diagnostic accuracies of cardiac magnetic resonance (CMR)-based left atrial (LA) volumetry and function, including LA strain analysis, for the detection of myocardial impairments in diseases of different etiologies such as hypertensive heart disease, Fabry disease and acute myocarditis.

Methods

Healthy volunteers (HV, n = 50) and patients with cardiomyopathies (n = 140), including patients with hypertensive heart disease (n = 40), Fabry disease (n = 49), and acute myocarditis (n = 51), underwent CMR at 3 T. Atrial volume and strain analysis based on long-axis cine acquisition was performed using a commercially available post-processing software.

Results

Patients exhibited impaired LA reservoir (28.60 ± 9.91 % vs. 41.27 ± 7.54 %), conduit (17.35 ± 7.72 % vs. 26.89 ± 5.25 %) and booster strain (11.30 ± 4.52 % vs. 14.61 ± 4.15 %) parameters compared to HV (all p < 0.001). In contrast, the volumetric values showed no significant difference between patients and HV (p > 0.05). Passive and total emptying fractions were significantly lower in patients (p < 0.001), while active emptying fraction did not differ (p > 0.05). Superior diagnostic accuracy for the LA reservoir strain demonstrated improved prognostic performance comparing to LA volumetric and functional parameters (area under the curve [AUC] 0.85 vs. e.g. passive emptying fraction AUC 0.78, p < 0.05).

Conclusion

LA strain parameters effectively distinguish patients with cardiac diseases presenting overlapping phenotypes from HV and outperform volumetric and traditional functional assessments of the LA.

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基于心脏磁共振成像的左心房应变分析对重叠型心脏病的诊断价值

本研究的主要目的是比较基于心脏磁共振（CMR）的左心房（LA）容量和功能（包括LA应变分析）对不同病因疾病（如高血压心脏病、法布里病和急性心肌炎）心肌损伤的诊断准确性。方法健康志愿者（HV, n = 50）和心肌病患者（n = 140），包括高血压心脏病（n = 40）、法布里病（n = 49）和急性心肌炎（n = 51），在3t进行CMR，使用市买后处理软件进行基于长轴影像采集的心房容量和应变分析。结果与HV相比，患者的LA储层（28.60±9.91% vs. 41.27±7.54%）、导管（17.35±7.72% vs. 26.89±5.25%）和增强应变（11.30±4.52% vs. 14.61±4.15%）参数受损(p <；0.001)。相比之下，患者和HV之间的体积值没有显着差异(p >；0.05)。被动排空分数和总排空分数在患者中显著降低(p <；0.001)，而活性排空分数无差异(p >；0.05)。与LA体积和功能参数(曲线下面积[AUC] 0.85 vs.被动排空分数AUC 0.78, p <；0.05)。结论LA菌株参数能有效区分心脏病患者的重叠表型和HV，优于LA容量和传统的功能评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.