Favorable impact of hepatitis C virus infection control on recurrence after surgical resection for intrahepatic cholangiocarcinoma

IF 3.4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Hepatology Research Pub Date : 2024-12-14 DOI:10.1111/hepr.14150

Masahiko Kinoshita, Hisashi Kosaka, Masaki Kaibori, Masaki Ueno, Satoshi Yasuda, Koji Komeda, Yusuke Yamamoto, Masaji Tani, Tsukasa Aihara, Hiroji Shinkawa, Shinya Hayami, Yasuko Matsuo, Nao Kawaguchi, Ryo Morimura, Haruki Mori, Takayoshi Nakajima, Shoji Kubo, Takeaki Ishizawa

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Abstract

Aim

Hepatitis C virus (HCV) infection is a risk factor of intrahepatic cholangiocarcinoma (ICC). However, the impact of HCV infection control status on prognosis after surgery for ICCs is still unclear.

Methods

This multicenter retrospective study included patients who underwent curative resection for ICCs. The sera of 56 patients tested positive for anti-HCV antibody and negative for hepatitis B surface antigen (HCV group). Additionally, the sera of 358 patients tested negative for anti-HCV antibody and hepatitis B surface antigen (NBNC group). In the HCV group, 33 of 56 patients achieved sustained virologic response (SVR) for HCV (SVR group), whereas 23 patients did not (non-SVR group). To investigate the prognostic impact of HCV infection control status in the whole study cohort and in patients with solitary ICC without lymph node metastasis (StN0 study cohort), the postoperative prognosis of the SVR, non-SVR, and NBNC groups was compared.

Results

In the whole study cohort, there were no significant differences in terms of recurrence-free survival (RFS) or overall survival among the three groups. Based on the multivariate Cox regression analysis, non-SVR was an independent unfavorable prognostic factor of RFS. In the StN0 study cohort, the non-SVR group had a significantly lower RFS than the NBNC and SVR groups. Based on the multivariate analysis, non-SVR was an independent unfavorable prognostic factor of RFS.

Conclusions

The achievement of SVR for HCV infection in patients with HCV infection-related ICCs is associated with a better RFS after surgery for HCV-related ICCs, particularly solitary ICC without lymph node metastasis.

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丙型肝炎病毒感染控制对肝内胆管癌手术切除后复发的有利影响

目的丙型肝炎病毒（HCV）感染是肝内胆管癌（ICC）的危险因素之一。然而，HCV感染控制状况对icc术后预后的影响尚不清楚。方法本研究为多中心回顾性研究，纳入了行根治性癌切除术的患者。56例患者血清抗HCV抗体阳性，乙型肝炎表面抗原阴性（HCV组）。此外，358例患者血清抗hcv抗体和乙型肝炎表面抗原检测呈阴性（NBNC组）。在HCV组中，56例患者中有33例实现了HCV的持续病毒学应答（SVR组），而23例患者没有（非SVR组）。为了研究HCV感染控制状况对整个研究队列和无淋巴结转移的孤立性ICC患者（StN0研究队列）预后的影响，比较SVR组、非SVR组和NBNC组的术后预后。结果在整个研究队列中，三组患者的无复发生存期（RFS）和总生存期均无显著差异。多因素Cox回归分析显示，非svr是RFS的一个独立不利预后因素。在StN0研究队列中，非SVR组的RFS显著低于NBNC组和SVR组。基于多因素分析，非svr是RFS的一个独立的不利预后因素。结论：HCV感染相关ICC患者SVR的实现与HCV相关ICC手术后更好的RFS相关，特别是无淋巴结转移的孤立性ICC。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatology Research 医学-胃肠肝病学

CiteScore

8.30

自引率

14.30%

发文量

124

审稿时长

1 months

期刊介绍： Hepatology Research (formerly International Hepatology Communications) is the official journal of the Japan Society of Hepatology, and publishes original articles, reviews and short comunications dealing with hepatology. Reviews or mini-reviews are especially welcomed from those areas within hepatology undergoing rapid changes. Short communications should contain concise definitive information.