Heat shock proteins in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic implications

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2025-05-01 DOI:10.1016/j.expneurol.2025.115284

Anliu Zhao , Guangming Zhang , Huayuan Wei, Xu Yan, Jiali Gan, Xijuan Jiang

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引用次数: 0

Abstract

Cerebral ischemia-reperfusion injury (CIRI) remains a significant challenge in ischemic stroke treatment. Heat shock proteins (HSPs), a cadre of molecular chaperones, have emerged as pivotal regulators in this pathological cascade. This review synthesizes the latest research on HSPs in CIRI from 2013 to 2024 focusing on their multifaceted roles and therapeutic potential. We explore the diverse cellular functions of HSPs, including regulation of oxidative stress, apoptosis, necroptosis, ferroptosis, autophagy, neuroinflammation, and blood-brain barrier integrity. Key HSPs, such as HSP90, HSP70, HSP32, HSP60, HSP47, and small HSPs, are investigated for their specific mechanisms of action in CIRI. Potential therapeutic strategies targeting HSPs, including HSP inhibitors, traditional Chinese medicine components, and gene therapy, are discussed. This review provides a comprehensive understanding of HSPs in CIRI and offers insights into the development of innovative neuroprotective treatments.

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热休克蛋白在脑缺血再灌注损伤中的作用：机制和治疗意义

脑缺血再灌注损伤（CIRI）仍然是缺血性脑卒中治疗中的一个重大挑战。热休克蛋白（HSPs）是一种分子伴侣蛋白，在这一病理级联中起着关键的调节作用。本文综述了2013年至2024年关于热休克蛋白在CIRI中的最新研究，重点介绍了热休克蛋白的多方面作用和治疗潜力。我们探讨了热休克蛋白的多种细胞功能，包括氧化应激、细胞凋亡、坏死、铁坏死、自噬、神经炎症和血脑屏障完整性的调节。研究了HSP90、HSP70、HSP32、HSP60、HSP47和小HSPs等关键HSPs在CIRI中的具体作用机制。讨论了针对热休克蛋白的潜在治疗策略，包括热休克蛋白抑制剂、中药成分和基因治疗。这篇综述提供了对CIRI中热休克蛋白的全面了解，并为创新神经保护治疗的发展提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.