Modelling of cardiac biventricular electromechanics with coronary blood flow to investigate the influence of coronary arterial motion on coronary haemodynamic

IF 4.9 2区医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer methods and programs in biomedicine Pub Date : 2025-04-22 DOI:10.1016/j.cmpb.2025.108800

Laila Fadhillah Ulta Delestri , Amr Al Abed , Socrates Dokos , Mohd Jamil Mohamed Mokhtarudin , Foo Ngai Kok , Neil W Bressloff , Bram G Sengers , Azam Ahmad Bakir

{"title":"Modelling of cardiac biventricular electromechanics with coronary blood flow to investigate the influence of coronary arterial motion on coronary haemodynamic","authors":"Laila Fadhillah Ulta Delestri , Amr Al Abed , Socrates Dokos , Mohd Jamil Mohamed Mokhtarudin , Foo Ngai Kok , Neil W Bressloff , Bram G Sengers , Azam Ahmad Bakir","doi":"10.1016/j.cmpb.2025.108800","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objective</h3><div>Coronary flow is strongly influenced by the geometry and motion of coronary arteries, which change periodically in response to myocardial contraction throughout the cardiac cycle. However, a computational framework integrating cardiac biventricular electromechanics with dynamic coronary artery flow using a simplified, yet comprehensive mathematical approach remains underexplored. This study aims to develop a coupled 3D model of cardiac biventricular electromechanics and coronary circulation, enabling simulation of the interplay between cardiac electrical activity, mechanical function and coronary flow.</div></div><div><h3>Methods</h3><div>A patient-specific biventricular electromechanical model encompasses the fibre orientation, electrophysiology, mechanical properties and an open-loop heart circulation is developed. The electromechanical model is simulated independently from the coronary circulation model. The model provides an input for the Navier-Stokes-based coronary flow model. A one-way coupling approach maps the biventricular motion to the coronary arteries, linking both components. To evaluate the influence of coronary arterial motion on coronary haemodynamic, simulations are performed for two scenarios: a moving and a non-moving (static) coronary artery model.</div></div><div><h3>Results</h3><div>Cardiac-induced coronary motion alters the pressure, velocity and flow profiles. Non-moving coronary arteries produce stable counter-rotating Dean-like vortices due to steady flow dominated by centrifugal forces, while the moving arteries disrupt these vortices as arterial curvature changes disturb the flow. Coronary motion significantly affects the wall shear stress, highlighting the necessity of incorporating arterial dynamics to investigate atherosclerosis.</div></div><div><h3>Conclusion</h3><div>The integrated biventricular-coronary model emphasizes the significance of background cardiac motion in coronary haemodynamic. The model offers a foundation for exploring myocardial perfusion mechanisms in realistic physiological settings.</div></div>","PeriodicalId":10624,"journal":{"name":"Computer methods and programs in biomedicine","volume":"267 ","pages":"Article 108800"},"PeriodicalIF":4.9000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer methods and programs in biomedicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169260725002172","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}

引用次数: 0

Abstract

Background and objective

Coronary flow is strongly influenced by the geometry and motion of coronary arteries, which change periodically in response to myocardial contraction throughout the cardiac cycle. However, a computational framework integrating cardiac biventricular electromechanics with dynamic coronary artery flow using a simplified, yet comprehensive mathematical approach remains underexplored. This study aims to develop a coupled 3D model of cardiac biventricular electromechanics and coronary circulation, enabling simulation of the interplay between cardiac electrical activity, mechanical function and coronary flow.

Methods

A patient-specific biventricular electromechanical model encompasses the fibre orientation, electrophysiology, mechanical properties and an open-loop heart circulation is developed. The electromechanical model is simulated independently from the coronary circulation model. The model provides an input for the Navier-Stokes-based coronary flow model. A one-way coupling approach maps the biventricular motion to the coronary arteries, linking both components. To evaluate the influence of coronary arterial motion on coronary haemodynamic, simulations are performed for two scenarios: a moving and a non-moving (static) coronary artery model.

Results

Cardiac-induced coronary motion alters the pressure, velocity and flow profiles. Non-moving coronary arteries produce stable counter-rotating Dean-like vortices due to steady flow dominated by centrifugal forces, while the moving arteries disrupt these vortices as arterial curvature changes disturb the flow. Coronary motion significantly affects the wall shear stress, highlighting the necessity of incorporating arterial dynamics to investigate atherosclerosis.

Conclusion

The integrated biventricular-coronary model emphasizes the significance of background cardiac motion in coronary haemodynamic. The model offers a foundation for exploring myocardial perfusion mechanisms in realistic physiological settings.

查看原文本刊更多论文

以冠状动脉血流为模型，研究冠状动脉运动对冠状动脉血流动力学的影响

背景和目的冠状动脉血流受冠状动脉的几何形状和运动的强烈影响，在整个心脏周期中，冠状动脉的形状和运动随心肌收缩而周期性变化。然而，利用一种简化而全面的数学方法，将心脏双心室电力学与动态冠状动脉血流结合起来的计算框架仍有待探索。本研究旨在建立心脏双心室电力学和冠状动脉循环的耦合三维模型，模拟心脏电活动、机械功能和冠状动脉血流之间的相互作用。方法建立了包括纤维取向、电生理、力学特性和开环心脏循环在内的患者特异性双心室机电模型。机电模型的模拟独立于冠状动脉循环模型。该模型为基于navier - stokes的冠状动脉血流模型提供了输入。单向耦合方法将双心室运动映射到冠状动脉，将两者连接起来。为了评估冠状动脉运动对冠状动脉血流动力学的影响，模拟了两种情况：移动和不移动（静态）冠状动脉模型。结果心肌梗死引起的冠状动脉运动改变了压力、流速和血流分布。不运动的冠状动脉由于受离心力支配的稳定流动而产生稳定的反向旋转的迪恩状涡流，而运动的冠状动脉由于动脉曲率的变化扰乱了流动而破坏了这些涡流。冠状动脉运动显著影响壁剪切应力，强调了结合动脉动力学来研究动脉粥样硬化的必要性。结论双心室-冠状动脉综合模型强调了背景心肌运动对冠状动脉血流动力学的影响。该模型为探索现实生理环境下心肌灌注机制提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Computer methods and programs in biomedicine 工程技术-工程：生物医学

CiteScore

12.30

自引率

6.60%

发文量

601

审稿时长

135 days

期刊介绍： To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.