Nickel-Catalyzed Gas-Free Reductive Carbonylation of Aryl Thianthrenium Salts to Access Aryl Amides and Aryl Thioesters

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-01 DOI:10.1021/acs.orglett.5c01203

Chen Chen, Lu-Yao Ding, Xiao-Xu Zhang, Guan-Shen Chen, Yan-Ping Zhu, Chunjie Ni, Bolin Zhu

引用次数: 0

Abstract

A nickel-catalyzed site-selective reductive carbonylation of arenes via aryl thianthrenium salts is described. Using Mo(CO)₆ as a convenient solid CO source and reductant and employing nitroarenes and sulfonyl chlorides as readily available nitrogen and sulfur sources, a range of aryl amides and aryl thioesters were successfully synthesized in moderate to good yields. The utility of this transformation is demonstrated through the synthesis of antimicrobial agents and the late-stage functionalization of biorelevant molecules.

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镍催化芳基硫铵盐的无气还原羰基化制备芳基酰胺和芳基硫酯

介绍了一种镍催化的芳基硫鎓盐羰基化反应。以Mo(CO)6为固体CO源和还原剂，以硝基芳烃和磺酰氯为氮源和硫源，以中高收率成功合成了一系列芳基酰胺和芳基硫酯。这种转化的效用通过抗菌药物的合成和生物相关分子的后期功能化来证明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.