RNA-binding proteins: a novel target for modulating glucose and lipid metabolism

Abstract

In a recent study published in Science, Chen and colleagues unveiled the mechanism by which hepatic alkylation repair homolog protein 5 (ALKBH5) regulates the glucagon receptor (GCGR) and mechanistic target of rapamycin complex 1 (mTORC1) signaling pathways via two independent mechanisms, thereby integrating the modulation of glucose and lipid metabolism homeostasis.¹ This research explores the regulation of metabolic homeostasis and the pathogenesis of metabolic diseases from the perspective of RNA-binding proteins, offering new drug targets for alleviating metabolic-associated fatty liver disease (MAFLD) and metabolic disorders.