Liver alterations found in patients with inflammatory bowel disease in a tertiary care center.

IF 3.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-04-01 DOI:10.1016/j.aohep.2025.101799

Kenia M. Bastida-Guadarrama , Jorge Luis De-León-Rendón , Viridiana López-Ladrón-de-Guevara , Santiago Camacho-Hernandez , Fátima Higuera-de-la-Tijera

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引用次数: 0

Abstract

Introduction and Objectives

Inflammatory bowel disease (IBD) encompasses two main conditions: Crohn's disease (CD) and ulcerative colitis (UC); the association between these diseases and liver diseases has been described. The objective of this work is to report the frequency of these alterations in a tertiary hospital.

Material and Patients

Observational, retrospective, descriptive, case series type. Patients with a diagnosis of IBD were included, including its two variants, CD and UC. An intentional search was carried out for alterations in the liver biochemical profile, findings in imaging methods and their clinical correlation, primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), autoimmune hepatitis (AIH), among other anatomical alterations. Qualitative data are expressed in percentages and quantitative data in mean±SD.

Results

62 patients were included, of which 31 were men and 31 were women, with a mean age of 42.74±15.47 years. Within this universe, there were 22 patients with CD (35.4%), 40 patients with UC (64.5%) who, according to the Montreal classification, were classified as E1=4 patients (10%), E2=12 patients (30%), E3=24 patients (60%). There were 16 patients (25.8%) who had some reported liver alteration, of which 8 (12.9%) with autoimmune liver diseases, 5 with PSC (8.06%), 2 with PBC (3.22%), 1 with HAI (1.61%). When intentionally searching for liver morphological alterations and as an incidental finding, they were found 3 (4.83%) simple hepatic cysts, 1 (1.61.%) hepatic hemangioma, and finally, 2 (3.22%) hepatitis C virus (HCV) infections.

Conclusions

IBD is commonly associated with autoimmune liver disorders. Likewise, the CUCI-PBC and CUCI-HAI relationship was found, which agrees with the international literature and is extrapolated with the population studied. Other incidental findings are also frequent, especially the high frequency of HCV compared to the general population.

查看原文本刊更多论文

三级保健中心发现炎症性肠病患者肝脏改变。

炎症性肠病（IBD）包括两种主要疾病：克罗恩病（CD）和溃疡性结肠炎（UC）；这些疾病和肝脏疾病之间的联系已经被描述。这项工作的目的是报告这些改变的频率在三级医院。材料和患者：观察性、回顾性、描述性、病例系列类型。诊断为IBD的患者包括其两种变体，CD和UC。对肝脏生化特征的改变、影像学检查结果及其临床相关性、原发性胆道胆管炎（PBC）、原发性硬化性胆管炎（PSC）、自身免疫性肝炎（AIH）以及其他解剖学改变进行了有意的研究。定性数据以百分比表示，定量数据以mean±SD表示。结果共纳入62例患者，其中男性31例，女性31例，平均年龄42.74±15.47岁。其中，CD患者22例（35.4%），UC患者40例（64.5%），根据Montreal分类分为E1=4例（10%），E2=12例（30%），E3=24例（60%）。16例（25.8%）报告有肝脏改变，其中自身免疫性肝病8例（12.9%），PSC 5例（8.06%），PBC 2例（3.22%），HAI 1例（1.61%）。当有意寻找肝脏形态学改变和偶然发现时，发现单纯性肝囊肿3例（4.83%），肝血管瘤1例（1.61%），丙型肝炎病毒（HCV）感染2例（3.22%）。结论sibd常与自身免疫性肝脏疾病相关。同样，CUCI-PBC和CUCI-HAI关系也被发现，这与国际文献一致，并根据所研究的人群进行了外推。其他偶然发现也很常见，特别是与一般人群相比，HCV的发生率较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.