Neutrophil/lymphocyte index as a prognostic predictor in patients with primary biliary cholangitis

IF 3.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-04-01 DOI:10.1016/j.aohep.2025.101819

Carlos S. Tinitana-Jumbo, Viridiana López-Ladrón-De Guevara, Karina Cazarín-Chávez, Paloma M. Diego-Salazar, Santiago Camacho-Hernández, María F. Higuera-De la Tijera

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引用次数: 0

Abstract

Introduction and Objectives

There is an inadequate response to first line treatment in 40% of patients with primary biliary cholangitis (PBC). The neutrophil/lymphocyte (N/L) index has been associated with poor long-term prognosis. Our objective was to evaluate the relationship of N/L index with prognosis at 1 year of treatment in patients with PBC.

Materials and Patients

This is an observational, retrospective, and analytical study of patients diagnosed with PBC, evaluating the prognosis according to the response to treatment measured by the GLOBE scoring system and its relationship with the N/L index at the time of diagnosis. Qualitative data are expressed as percentages and quantitative data as mean±SD. Statistical comparison was performed with the two-tailed unpaired Student´s t-test or chi-square, as appropriate. Alpha=0.005.

Results

A total of 128 patients (54.21±10.26 years, 93.8% women) with PBC were included. According to the GLOBE score, 27.3% were classified as “good prognosis” and 72.7% as “poor prognosis”. The N/L index was lower in the good prognosis group (2.29±0.99) compared to the poor prognosis group (3.06±1.48, p=0.005), also the Meld-Na scoring system was higher in the poor prognosis group (11.57±4.96 vs. 7.62±1.33, p=0.005). Mortality in the population was 9.4% all belonging to the poor prognosis group.

Conclusions: The N/L index in patients diagnosed with PBC is related to the prognosis after one year of treatment as measured by the GLOBE score. It is necessary to prospectively assess the findings in order to be able to determine their prognostic utility at the time of diagnosis.

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中性粒细胞/淋巴细胞指数作为原发性胆管炎患者的预后预测因子

40%的原发性胆管炎（PBC）患者对一线治疗反应不足。中性粒细胞/淋巴细胞（N/L）指数与不良的长期预后有关。我们的目的是评估PBC患者治疗1年时N/L指数与预后的关系。材料和患者本研究是一项观察性、回顾性和分析性研究，针对诊断为PBC的患者，根据GLOBE评分系统测量的治疗反应及其与诊断时N/L指数的关系来评估预后。定性数据以百分比表示，定量数据以mean±SD表示。采用双尾非配对学生t检验或卡方检验进行统计比较。α= 0.005。结果共纳入128例PBC患者（54.21±10.26岁，女性93.8%）。根据GLOBE评分，27.3%的患者预后良好，72.7%的患者预后较差。预后良好组N/L指数（2.29±0.99）低于预后差组（3.06±1.48,p=0.005），预后差组Meld-Na评分系统较高（11.57±4.96比7.62±1.33,p=0.005）。死亡率为9.4%，均属于预后不良组。结论：诊断为PBC患者的N/L指数与治疗1年后的预后有关，以GLOBE评分衡量。有必要对这些发现进行前瞻性评估，以便能够在诊断时确定其预后效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.