Sarcopenia in patients with liver cirrhosis according to hepatic functional reserve

IF 4.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Annals of hepatology Pub Date : 2025-04-01 DOI:10.1016/j.aohep.2025.101855

Nayeli X. Ortiz-Olvera , Josue G. Junco-Enciso , Ricardo Cordova-Ramirez , Vanesa J. Gutierrez-Bailon , Segundo Moran-Villota

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引用次数: 0

Abstract

Introduction and Objectives

Computed tomography (CT) is one of the most used and validated methods for the non-invasive diagnosis of sarcopenia; its measurement is not affected by the presence of obesity or ascites. The objective of the study was to know the frequency of sarcopenia in patients with liver cirrhosis with different degrees of liver reserve.

Materials and Patients

Patients who underwent liver function tests and an abdominal CT were included. The Child-Pugh index (CP) was obtained, and the skeletal muscle index (SMI) was calculated from the measurement of the cross-sectional area of the psoas muscle at the level of the third lumbar vertebra and normalized by the height of the patients (reference values for sarcopenia (Men <50cm2/m2; women <39cm2/m2).

Results

110 patients were included (75 women and 35 men) with an average age of 54±11 years, in CP A (n=21), CP B (n=53), and CP C (n=36); with a history of non-alcoholic fatty liver disease (n=36), hepatitis C virus infection (n=19), primary biliary cholangitis (n=15), excessive alcohol consumption (n=10), and other etiologies (n=30). The SMI was significantly higher in Child-Pugh A patients (48.15±9 cm2/m2) compared to Child-Pugh B (44.19±9 cm2/m2) and Child-Pugh C (41.20±7 cm2/m2) patients. The frequency of sarcopenia was 59% (CP A: 33.3%; CP B: 43.4%; CB C: 66.6%).

Conclusions

The results of the study confirm that sarcopenia is common in patients with liver cirrhosis and increases as liver reserve deteriorates.

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肝硬化患者骨骼肌减少症的诊断依据肝功能储备

计算机断层扫描（CT）是肌少症无创诊断中最常用和最有效的方法之一；其测量不受肥胖或腹水存在的影响。本研究的目的是了解不同肝储备程度的肝硬化患者肌肉减少症的发生频率。资料和患者包括接受肝功能检查和腹部CT检查的患者。计算Child-Pugh指数（CP），通过测量第三腰椎水平腰肌横截面积计算骨骼肌指数（SMI），并根据患者身高归一化(骨骼肌减少症参考值(Men <50cm2/m2；女人& lt; 39厘米2 / m2)。结果共纳入110例患者（女性75例，男性35例），平均年龄54±11岁，分别为CP A （n=21）、CP B （n=53）、CP C (n=36)；有非酒精性脂肪性肝病（n=36）、丙型肝炎病毒感染（n=19）、原发性胆管炎（n=15）、过度饮酒（n=10）和其他病因史（n=30）。Child-Pugh A组患者的SMI（48.15±9 cm2/m2）明显高于Child-Pugh B组（44.19±9 cm2/m2）和Child-Pugh C组（41.20±7 cm2/m2）。肌少症发生率为59% (CP A: 33.3%；Cp b: 43.4%；c: 66.6%)。结论肌少症在肝硬化患者中较为常见，并随着肝储备的恶化而增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.60%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Annals of Hepatology publishes original research on the biology and diseases of the liver in both humans and experimental models. Contributions may be submitted as regular articles. The journal also publishes concise reviews of both basic and clinical topics.