Scientometric analysis of evolution in sex-specific MSC therapy for cardiovascular diseases

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-04-29 DOI:10.1016/j.bbadis.2025.167878

Elika Verma, Mehak Gupta, Riley Sierhuis, Sanjiv Dhingra

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Abstract

Background

Mesenchymal stem cell (MSC) therapy for cardiovascular diseases has shown promise; however, sex-specific differences remain understudied. This scientometric analysis provides the first comprehensive overview of sex-specific differences in mesenchymal stem cell (MSC) therapy for cardiovascular diseases, spanning from 1947 to 2024.

Methods

We analyzed 61,029 publications using advanced bibliometric tools to identify research hotspots, publication trends, and collaborative networks.

Results

A significant shift in research focus has been observed in the field of mesenchymal stem cell (MSC) therapy for cardiovascular diseases, transitioning from broad cardiovascular concepts in the 20th century to specialized sex-specific considerations in the 21st century. Furthermore, in the 21st-century research landscape, the formation of two distinct clusters for “male” and “female” in VOSviewer-generated network visualizations is highly important, emphasizing the growing recognition of sex-specific differences in MSC therapy responses and outcomes. This shift was accompanied by a marked increase in terminology related to sex-specific differences, with keywords like “genetic association” and “body mass index” forming distinct clusters in recent years.

Conclusions

This analysis underscores the critical need for sex-specific considerations in MSC therapy for cardiovascular disease. The emergence of distinct male and female clusters in research networks emphasizes the importance of tailoring approaches based on sex differences. Key areas identified for future investigation include the role of epigenetics in mediating sex-specific effects and the potential of sex-matched MSC-derived exosomes. These findings pave the way for more effective and personalized approaches in cardiovascular regenerative medicine, potentially leading to improved outcomes through sex-specific therapeutic strategies.

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性别特异性MSC治疗心血管疾病进化的科学计量学分析

间充质干细胞（MSC）治疗心血管疾病已显示出前景；然而，性别差异仍未得到充分研究。这项科学计量学分析首次全面概述了1947年至2024年间间充质干细胞（MSC）治疗心血管疾病的性别特异性差异。方法利用先进的文献计量学工具对61,029篇文献进行分析，确定研究热点、出版趋势和合作网络。结果：间充质干细胞（MSC）治疗心血管疾病领域的研究重点发生了重大转变，从20世纪的广泛心血管概念转变为21世纪的专门性别特异性考虑。此外，在21世纪的研究前景中，vosviewer生成的网络可视化中“男性”和“女性”两个不同集群的形成非常重要，这强调了对MSC治疗反应和结果的性别特异性差异的日益认识。这一转变伴随着与性别差异相关的术语的显著增加，近年来，“遗传关联”和“体重指数”等关键词形成了明显的集群。结论：该分析强调了在骨髓间质干细胞治疗心血管疾病时考虑性别特异性的关键必要性。研究网络中明显的男性和女性集群的出现强调了基于性别差异定制方法的重要性。确定的未来研究的关键领域包括表观遗传学在介导性别特异性效应中的作用以及性别匹配的msc衍生外泌体的潜力。这些发现为更有效和个性化的心血管再生医学方法铺平了道路，有可能通过性别特异性治疗策略改善结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.