Health status in stage B heart failure from diabetic cardiomyopathy baseline results from ARISE-HF

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2025-04-25 DOI:10.1016/j.jdiacomp.2025.109059

Tariq Jamal Siddiqi , Yuxi Liu , Faiez Zannad , W.H. Wilson Tang , Scott Solomon , Julio Rosenstock , Riccardo Perfetti , Thomas H. Marwick , Gregory D. Lewis , Carolyn S.P. Lam , Nasrien E. Ibrahim , Justin Ezekowitz , Stefano Del Prato , Javed Butler , James L. Januzzi

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引用次数: 0

Abstract

Aims

Assess the determinants of health status and its correlation with key parameters in individuals with diabetic cardiomyopathy (DbCM).

Methods

In the ARISE-HF trial, the Kansas City Cardiomyopathy Questionnaire (KCCQ), cardiopulmonary exercise testing (CPET), Physical Activity Scale for the Elderly (PASE) score, echocardiographic, and laboratory assessments were performed at baseline in 691 persons with DbCM.

Results

Study participants with lower KCCQ-Clinical Summary Score (CSS) were predominantly women, had poorer kidney function, higher body-mass index and natriuretic peptides, and lower hemoglobin levels. Lower KCCQ-CSS scores were associated with shorter CPET duration, lower peak exercise oxygen consumption (VO₂) and lower PASE scores, but the correlations were weak (CPET duration: r = 0.14, 95 % CI: 0.07–0.22; peak VO₂: r = 0.21, 95 % CI: 0.14–0.28; PASE score: r = 0.19, 95 % CI: 0.11–0.26), indicating that although worse health status was linked to poorer function and activity, the strength of these relationships was limited. No meaningful associations were observed between KCCQ-CSS and echocardiographic measurements, cardiac biomarkers, or kidney function.

Conclusion

Health status in Stage B heart failure due to DbCM is frequently impaired. Among those with DbCM the KCCQ is only weakly correlated with the CPET parameters and PASE score implying these assessments provide unique information.

Trial registration

ARISE-HF, NCT04083339

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糖尿病性心肌病B期心力衰竭患者的健康状况

目的评估糖尿病性心肌病（DbCM）患者健康状况的决定因素及其与关键参数的相关性。方法在rise - hf试验中，对691例DbCM患者进行基线时的堪萨斯城心肌病问卷（KCCQ）、心肺运动测试（CPET）、老年人体力活动量表（PASE）评分、超声心动图和实验室评估。结果kccq -临床总结评分（CSS）较低的研究参与者主要是女性，肾功能较差，体重指数和利钠肽较高，血红蛋白水平较低。较低的KCCQ-CSS评分与较短的CPET持续时间、较低的峰值运动耗氧量（VO 2）和较低的PASE评分相关，但相关性较弱(CPET持续时间：r = 0.14, 95% CI: 0.07-0.22；峰值VO 2: r = 0.21, 95% CI: 0.14-0.28；PASE评分：r = 0.19, 95% CI: 0.11-0.26)，表明尽管较差的健康状况与较差的功能和活动有关，但这些关系的强度是有限的。KCCQ-CSS与超声心动图测量、心脏生物标志物或肾功能之间未观察到有意义的关联。结论DbCM所致B期心力衰竭患者的健康状况经常受到损害。在DbCM患者中，KCCQ与CPET参数和PASE评分仅呈弱相关，这意味着这些评估提供了独特的信息。试验注册号：arise - hf， NCT04083339

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.