Antimony (III) oxide and calcium phosphate doped with carbon nanotubes in PVA/HA matrix for wound dressing applications

IF 4.3 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Chemistry and Physics Pub Date : 2025-04-22 DOI:10.1016/j.matchemphys.2025.130933

Mohamed Tharwat Elabbasy , Fahad Awwadh Almarshadi , Muteb H. Alshammari , Mohamed S. Othman , Mohamed E. Ghoniem , Mai A. Samak , Doaa Domyati , M.A. El-Morsy , M.O. Farea

{"title":"Antimony (III) oxide and calcium phosphate doped with carbon nanotubes in PVA/HA matrix for wound dressing applications","authors":"Mohamed Tharwat Elabbasy , Fahad Awwadh Almarshadi , Muteb H. Alshammari , Mohamed S. Othman , Mohamed E. Ghoniem , Mai A. Samak , Doaa Domyati , M.A. El-Morsy , M.O. Farea","doi":"10.1016/j.matchemphys.2025.130933","DOIUrl":null,"url":null,"abstract":"<div><div>This study investigates the development of nanocomposite wound dressing films composed of a poly(vinyl alcohol)/hyaluronic acid (PVA/HA) matrix incorporating antimony(III) oxide (Sb2O3), calcium phosphate (Ca3(PO4)2), and carbon nanotubes (CNTs). The physicochemical and biological properties of these cast films were systematically evaluated. Contact angle measurements revealed enhanced hydrophilicity upon nanoparticle incorporation, with the Ca3(PO4)2/Sb2O3@PVA/HA film demonstrating the highest wettability, exhibiting a contact angle of 32.3 ± 2.46°. The refractive index varied from 1.69 for PVA/HA to 1.71 for Sb2O3@PVA/HA. In vitro cytotoxicity assays confirmed biocompatibility, showing a cell viability ratio of approximately 123 % for human normal cells after three days of culture. Surface morphology analysis indicated significant alterations with the addition of nanoparticles. Notably, the Ca3(PO4)2/Sb2O3/CNT@PVA/HA film exhibited a substantial inhibition zone of 25.9 ± 1.1 mm against Escherichia coli. This film exhibited a porosity of 48.1 ± 6.1 %, with pore sizes ranging from 120 to 350 nm, indicating a potential for enhanced cellular infiltration and proliferation. The release of calcium (Ca2+) and antimony (Sb3+) ions reached 37 ± 2.7 ppm and 11 ± 1.2 ppm, respectively, after 16 h. The films exhibited significant swelling behavior, reaching 450.6 ± 15.9 % after 12 h, accompanied by an elongation at break of 168.13 ± 11.29 % and a tensile strength of 35.94 ± 0.64 MPa. These results collectively demonstrate the potential of these nanocomposite films for diverse biomedical applications, particularly in wound healing.</div></div>","PeriodicalId":18227,"journal":{"name":"Materials Chemistry and Physics","volume":"341 ","pages":"Article 130933"},"PeriodicalIF":4.3000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Chemistry and Physics","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0254058425005796","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

This study investigates the development of nanocomposite wound dressing films composed of a poly(vinyl alcohol)/hyaluronic acid (PVA/HA) matrix incorporating antimony(III) oxide (Sb₂O₃), calcium phosphate (Ca₃(PO₄)₂), and carbon nanotubes (CNTs). The physicochemical and biological properties of these cast films were systematically evaluated. Contact angle measurements revealed enhanced hydrophilicity upon nanoparticle incorporation, with the Ca₃(PO₄)₂/Sb₂O₃@PVA/HA film demonstrating the highest wettability, exhibiting a contact angle of 32.3 ± 2.46°. The refractive index varied from 1.69 for PVA/HA to 1.71 for Sb₂O₃@PVA/HA. In vitro cytotoxicity assays confirmed biocompatibility, showing a cell viability ratio of approximately 123 % for human normal cells after three days of culture. Surface morphology analysis indicated significant alterations with the addition of nanoparticles. Notably, the Ca₃(PO₄)₂/Sb₂O₃/CNT@PVA/HA film exhibited a substantial inhibition zone of 25.9 ± 1.1 mm against Escherichia coli. This film exhibited a porosity of 48.1 ± 6.1 %, with pore sizes ranging from 120 to 350 nm, indicating a potential for enhanced cellular infiltration and proliferation. The release of calcium (Ca²⁺) and antimony (Sb³⁺) ions reached 37 ± 2.7 ppm and 11 ± 1.2 ppm, respectively, after 16 h. The films exhibited significant swelling behavior, reaching 450.6 ± 15.9 % after 12 h, accompanied by an elongation at break of 168.13 ± 11.29 % and a tensile strength of 35.94 ± 0.64 MPa. These results collectively demonstrate the potential of these nanocomposite films for diverse biomedical applications, particularly in wound healing.

查看原文本刊更多论文

在PVA/HA基质中掺杂碳纳米管的氧化锑和磷酸钙用于伤口敷料

本研究研究了由聚（乙烯醇）/透明质酸（PVA/HA）基质结合氧化锑（Sb2O3）、磷酸钙（Ca3(PO4)2）和碳纳米管（CNTs）组成的纳米复合伤口敷料膜的开发。系统地评价了这些铸膜的物理化学和生物性能。接触角测量显示纳米颗粒掺入后亲水性增强，Ca3(PO4)2/Sb2O3@PVA/HA膜的润湿性最高，接触角为32.3±2.46°。PVA/HA的折射率为1.69，Sb2O3@PVA/HA的折射率为1.71。体外细胞毒性试验证实了生物相容性，培养3天后，人类正常细胞的细胞存活率约为123%。表面形貌分析表明，纳米颗粒的加入显著改变了表面形貌。值得注意的是，Ca3(PO4)2/Sb2O3/CNT@PVA/HA膜对大肠杆菌的抑制区为25.9±1.1 mm。该膜的孔隙率为48.1±6.1%，孔径范围为120 ~ 350 nm，具有增强细胞浸润和增殖的潜力。16 h后，钙离子（Ca2+）和锑离子（Sb3+）的释放量分别达到37±2.7 ppm和11±1.2 ppm。薄膜表现出明显的膨胀行为，12 h后达到450.6±15.9%，断裂伸长率为168.13±11.29%，抗拉强度为35.94±0.64 MPa。这些结果共同证明了这些纳米复合膜在各种生物医学应用方面的潜力，特别是在伤口愈合方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Materials Chemistry and Physics 工程技术-材料科学：综合

CiteScore

8.70

自引率

4.30%

发文量

1515

审稿时长

69 days

期刊介绍： Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.