A novel diagnosis method utilizing MDBO-SVM and imaging genetics for Alzheimer's disease

IF 5.4 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Yu Xin , Jinhua Sheng , Qiao Zhang , Yan Song , Luyun Wang , Ze Yang
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引用次数: 0

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder, yet its underlying mechanisms remain elusive. Early and accurate diagnosis is crucial for timely intervention and disease management. In this paper, a multi-strategy improved dung beetle optimizer (MDBO) was proposed to establish a new framework for AD diagnosis. The unique aspect of this algorithm lies in its integration of the Osprey Optimization Algorithm, Lévy flight, and adaptive t-distribution. This combination endows MDBO with superior global search capabilities and the ability to avoid local optima. Then, we presented a novel fitness function for integrating imaging genetics data. In experiments, MDBO demonstrated outstanding performance on the CEC2017 benchmark functions, proving its effectiveness in optimization problems. Furthermore, it was used to classify individuals with AD, mild cognitive impairment (MCI), and control normal (CN) using limited features. In the multi-classification of CN, MCI, and AD, the algorithm achieved excellent results, with an average accuracy of 81.7 % and a best accuracy of 92 %. Overall, the proposed MDBO algorithm provides a more comprehensive and efficient diagnostic tool, offering new possibilities for early intervention and disease progression control.
一种基于mbo - svm和影像遗传学的阿尔茨海默病诊断方法
阿尔茨海默病(AD)是最常见的神经退行性疾病,但其潜在机制尚不清楚。早期准确诊断对及时干预和疾病管理至关重要。本文提出了一种改进的多策略屎壳虫优化器(MDBO),建立了一种新的AD诊断框架。该算法的独特之处在于将鱼鹰优化算法、lsamvy飞行和自适应t分布相结合。这种组合赋予MDBO卓越的全局搜索能力和避免局部最优的能力。然后,我们提出了一种新的适应度函数来整合成像遗传学数据。在实验中,MDBO在CEC2017基准函数上表现出了出色的性能,证明了其在优化问题上的有效性。此外,它还用于使用有限的特征对AD,轻度认知障碍(MCI)和控制正常(CN)的个体进行分类。在CN、MCI和AD的多重分类中,该算法取得了优异的结果,平均准确率为81.7 %,最佳准确率为92 %。总的来说,本文提出的MDBO算法提供了一种更全面、更有效的诊断工具,为早期干预和疾病进展控制提供了新的可能性。
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来源期刊
CiteScore
10.70
自引率
3.50%
发文量
71
审稿时长
26 days
期刊介绍: The purpose of the journal Computerized Medical Imaging and Graphics is to act as a source for the exchange of research results concerning algorithmic advances, development, and application of digital imaging in disease detection, diagnosis, intervention, prevention, precision medicine, and population health. Included in the journal will be articles on novel computerized imaging or visualization techniques, including artificial intelligence and machine learning, augmented reality for surgical planning and guidance, big biomedical data visualization, computer-aided diagnosis, computerized-robotic surgery, image-guided therapy, imaging scanning and reconstruction, mobile and tele-imaging, radiomics, and imaging integration and modeling with other information relevant to digital health. The types of biomedical imaging include: magnetic resonance, computed tomography, ultrasound, nuclear medicine, X-ray, microwave, optical and multi-photon microscopy, video and sensory imaging, and the convergence of biomedical images with other non-imaging datasets.
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