Comprehensive evaluation of early-phase FP-CIT PET as a substitute for brain FDG PET in parkinsonism

IF 7 2区医学 Q1 BIOLOGY

Computers in biology and medicine Pub Date : 2025-04-28 DOI:10.1016/j.compbiomed.2025.110177

Hye Joo Son , Chanwoo Kim , Hyung Jin Choi

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引用次数: 0

Abstract

Background

Early-phase F-18 FP-CIT PET/CT (PET_FP-CIT) has been reported to possibly replace FDG PET/CT (PET_FDG) in the differential diagnosis of parkinsonism. We investigated the correlation between PET_FP-CIT and PET_FDG to explore their potential interchangeability.

Method

Our retrospective study included 187 participants, categorized into Parkinson's disease (PD), atypical parkinsonian disorders (APD), and participants with intact dopamine transporters (DAT_intact). We analyzed the correlation of standardized uptake value ratios (SUVR) from early-phase PET_FP-CIT and PET_FDG scans across 23 different brain volumes-of-interest using Pearson's correlation analysis. We conducted this analysis for all participants collectively and then separately for each group.

Results

For all participants without grouping, a moderate correlation (with correlation coefficients R ranging from 0.360 in right putamen to 0.530 in left caudate nucleus) was observed between Early-phase PET_FP-CIT and PET_FDG. PD group showed a weak to moderate correlation (0.226 in left frontal cortex ≤ R ≤ 0.555 in right cerebellum). APD group revealed a moderate correlation with R ranging from 0.488 in right cerebellum to 0.692 in right occipital cortex. Conversely, a lack of correlation in specific areas for DAT_intact group indicated distinctions between the modalities.

Conclusions

Our study showed interchangeability with a moderate correlation between early-phase PET_FP-CIT and PET_FDG. However, careful consideration is needed for DAT_intact group.

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早期FP-CIT PET替代脑FDG PET在帕金森病中的综合评价

早期F-18 FP-CIT PET/CT （PETFP-CIT）有报道可能取代FDG PET/CT （PETFDG）用于帕金森病的鉴别诊断。我们研究了PETFP-CIT和PETFDG之间的相关性，以探索它们潜在的互换性。方法回顾性研究纳入187例帕金森病（PD）、非典型帕金森病（APD）和多巴胺转运体完整（datunchanged）患者。我们使用Pearson相关分析分析了标准化摄取值比（SUVR）在23个不同脑兴趣容量的早期PETFP-CIT和PETFDG扫描中的相关性。我们对所有参与者进行了集体分析，然后对每个组分别进行了分析。结果在未分组的所有参与者中，早期PETFP-CIT与PETFDG之间存在中度相关（相关系数R范围为右壳核0.360至左尾状核0.530）。PD组呈弱至中度相关性（左额叶皮质0.226≤R≤右小脑0.555）。APD组与右小脑R为0.488 ~右枕皮质R为0.692，呈中等相关性。相反，在dat完好组的特定区域缺乏相关性表明两种模式之间存在差异。结论早期PETFP-CIT与PETFDG具有一定的互换性。然而，对于dat完整组，需要仔细考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computers in biology and medicine 工程技术-工程：生物医学

CiteScore

11.70

自引率

10.40%

发文量

1086

审稿时长

74 days

期刊介绍： Computers in Biology and Medicine is an international forum for sharing groundbreaking advancements in the use of computers in bioscience and medicine. This journal serves as a medium for communicating essential research, instruction, ideas, and information regarding the rapidly evolving field of computer applications in these domains. By encouraging the exchange of knowledge, we aim to facilitate progress and innovation in the utilization of computers in biology and medicine.