meta-Selective thiofluoroalkylation of substituted pyridines via Zincke imines

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-04-25 DOI:10.1039/d5qo00533g

Will Connor Hartley, Arnau Huerta, Júlia C. Negredo, Omar Boutureira

引用次数: 0

Abstract

Zincke imines enable the regioselective thiofluoroalkylation of substituted pyridines, grating access to thioalkylated pyridines bearing a range of fluorination patterns. Crucial to success of this strategy was the use of saccharine-derived thiofluoroalkylating reagents, which, upon reaction with TMSCl, generate electrophilic sulfenyl chlorides.

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通过锌克亚胺对取代的吡啶进行元选择性硫代氟烷基化反应

锌克亚胺使取代吡啶的区域选择性硫代氟烷基化，光栅获得具有一系列氟化模式的硫代烷基化吡啶。这一战略取得成功的关键是使用了糖精衍生的硫代氟烷基化试剂，这些试剂与tmsl反应后产生亲电性亚砜酰氯。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.