Differential Induction of Endoplasmic Reticulum Stress Signaling by Antibody Isotypes: Implications for Plasma Cell Differentiation

IF 4.5 3区医学 Q2 IMMUNOLOGY

European Journal of Immunology Pub Date : 2025-04-25 DOI:10.1002/eji.202451428

Kunie Obayashi, Tomomitsu Doi, Kazuhiro Sumida, Motoyoshi Endo

引用次数: 0

Abstract

IgE induces stronger ER stress than IgG1 due to its constant region, particularly the Cε3 domain, which binds BiP more efficiently. Genetic and structural analyses confirmed IgE's higher BiP-binding capacity. ER stress, driven by IRE1-XBP1 signaling, regulates plasma cell differentiation, suggesting IgE-specific mechanisms in immune responses.

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抗体同型诱导内质网应激信号的差异：对浆细胞分化的影响

IgE比IgG1诱导更强的内质网应激，这是由于其恒定区域，特别是Cε3结构域更有效地结合BiP。遗传和结构分析证实IgE具有较高的bip结合能力。内质网应激由IRE1-XBP1信号驱动，调节浆细胞分化，提示ige特异性免疫应答机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.