Ionic liquids as transdermal drug carriers: A review of recent advancements

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Liquids Pub Date : 2025-04-17 DOI:10.1016/j.molliq.2025.127595

Rongtian Lin , Jiaping Qian , Jiaheng Zhang , Huijing Li , Yanchao Wu

引用次数: 0

Abstract

Ionic liquids (ILs) comprise organic cations and either inorganic or organic anions and exist in a liquid state at room temperature. Owing to their simple preparation, good stability, strong solubility, and adjustable structure, ILs have been widely explored in biomedicine. ILs increase the solubility and stability of insoluble drugs, are biocompatible, and promote transdermal drug penetration, rendering them potential carriers in transdermal drug delivery systems. In addition, they can form active pharmaceutical ingredient ILs, improve the bioavailability of drugs, enhance efficacy, and overcome current limitations in transdermal drug delivery systems. This review comprehensively evaluates the development history, classification, and design of ILs, focusing on their applications and safety. Moreover, it summarizes new IL-based drug delivery preparations and provides references for further research and development of ILs in transdermal drug delivery systems.

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离子液体作为透皮药物载体的研究进展

离子液体由有机阳离子和无机或有机阴离子组成，在室温下呈液态存在。由于其制备简单、稳定性好、溶解度强、结构可调等优点，在生物医学领域得到了广泛的应用。il增加了不溶性药物的溶解度和稳定性，具有生物相容性，促进药物透皮渗透，使其成为透皮给药系统的潜在载体。此外，它们可以形成活性药物成分il，提高药物的生物利用度，增强疗效，克服目前透皮给药系统的局限性。本文综述了人工智能的发展历史、分类和设计，重点介绍了人工智能的应用和安全性。总结了基于白介素的新型给药制剂，为进一步研究和开发白介素在透皮给药系统中的应用提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.