Indole-3-Carbinol Mechanisms Combating Chemicals and Drug Toxicities

IF 3.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biochemical and Molecular Toxicology Pub Date : 2025-04-23 DOI:10.1002/jbt.70280

Marian N. Gerges, Thoria Donia, Tarek M. Mohamed

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Abstract

The toxicity of chemicals and drugs is a common crisis worldwide. Therefore, the search for protective compounds is growing. Natural compounds such as indole-3-carbinol (I3C) derived from cruciferous vegetables are preferred since they are safe for humans and the environment. This review focuses on I3C potential role in preventing and repairing damage caused by chemicals and drugs. Interestingly, I3C ameliorates hepatotoxicity induced by carbon tetrachloride (CCl₄), diethylnitrosamine (DENA), alcohol, gold nanoparticles, and microbial toxins. Additionally, it inhibits carcinogenesis induced by different chemicals and prevents the deleterious effects of different antineoplastic drugs including cisplatin, doxorubicin (DOX), and trabectidin on normal tissues. Moreover, it reduces fetal malformation and protects against micronuclei formation and calstogenecity induced by cyclophosphamide (CP) in bone marrow cells. It also attenuates methotrexate (MTX)-induced hepatotoxicity, mitigates neurotoxicity caused by thioacetamide and clonidine, and protects against aspirin side effects in gastric mucosa. Furthermore, its nanoparticles inhibit neuronal damage caused by glutamate and rotenone. Thus, I3C prevents the toxicities caused by chemicals in the surrounding environment as well as those of consumed drugs.

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吲哚-3-甲醇对抗化学品和药物毒性的机制

化学品和药物的毒性是世界范围内的共同危机。因此，对保护性化合物的研究正在增长。从十字花科蔬菜中提取的天然化合物如吲哚-3-甲醇（I3C）是首选，因为它们对人类和环境都是安全的。本文综述了I3C在预防和修复化学物质和药物损伤中的潜在作用。有趣的是，I3C可改善由四氯化碳（CCl4）、二乙基亚硝胺（DENA）、酒精、金纳米颗粒和微生物毒素引起的肝毒性。此外，它还能抑制不同化学物质诱导的癌变，防止顺铂、多柔比星（DOX）、曲比丁等不同抗肿瘤药物对正常组织的有害作用。此外，它还能减少胎儿畸形，并对环磷酰胺（CP）诱导的骨髓细胞微核形成和胼胝质形成具有保护作用。它还能减轻甲氨蝶呤（MTX）引起的肝毒性，减轻硫乙酰胺和可乐定引起的神经毒性，并防止阿司匹林对胃粘膜的副作用。此外，其纳米颗粒可抑制谷氨酸和鱼藤酮引起的神经元损伤。因此，I3C可以防止由周围环境中的化学物质以及消耗的药物引起的毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biochemical and Molecular Toxicology 生物-毒理学

CiteScore

5.80

自引率

2.80%

发文量

277

审稿时长

6-12 weeks

期刊介绍： The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.