Extracellular Vesicles: Hermes between cancers and lymph nodes

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2025-04-21 DOI:10.1016/j.canlet.2025.217735

Lei-Ming Cao , Yu-Zhong Qiu , Zi-Zhan Li , Guang-Rui Wang , Yao Xiao , Han-Yue Luo , Bing Liu , Qiuji Wu , Lin-Lin Bu

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引用次数: 0

Abstract

Cancer is one of the main causes of death and a major obstacle to increasing life expectancy in all countries of the world. Lymph node metastasis (LNM) of in cancer patients indicates poor prognosis and it is an important indication to determine the therapeutic regime. Therefore, more attention should be given to the molecular mechanics of tumor lymphangiogenesis and LNM. Extracellular vesicles (EVs) are nanoscale cargo-bearing membrane vesicles that can serve as key mediators for the intercellular communication. Like Hermes, the messenger of the Greek gods, EVs can be secreted by tumor cells to regulate the LNM process. Many evidence has proved the clinical correlation between EVs and LNM in various cancer types. EVs plays an active role in the process of metastasis by expressing its connotative molecules, including proteins, nucleic acids, and metabolites. However, the clear role of EVs in the process of cancer LNM has not been thoroughly studied yet. In this review, we will summarize the clinical and mechanical findings of EVs regulating role on cancer LNM, and discuss the advanced modification of the research proposal. We propose the “PUMP” principle of EVs in LNM, including Preparation, Unleash, Migration, and Planting.

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细胞外囊泡：肿瘤和淋巴结之间的Hermes

癌症是造成死亡的主要原因之一，也是世界各国提高预期寿命的主要障碍。肿瘤患者的淋巴结转移（LNM）提示预后不良，是确定治疗方案的重要指标。因此，肿瘤淋巴管生成和淋巴细胞转移的分子力学应引起更多的关注。细胞外囊泡（EVs）是纳米级承载货物的膜囊泡，可以作为细胞间通讯的关键介质。就像希腊众神的信使Hermes一样，EVs可以由肿瘤细胞分泌来调节LNM过程。许多证据证明了EVs与各种癌症类型的LNM之间的临床相关性。ev通过表达其内含分子，包括蛋白质、核酸和代谢物，在转移过程中发挥积极作用。然而，ev在癌变LNM过程中的明确作用尚未得到深入研究。在这篇综述中，我们将总结ev调控肿瘤LNM的临床和力学结果，并讨论研究方案的进一步修改。我们提出了电动汽车在LNM中的“PUMP”原则，即准备、释放、迁移、种植。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.