CD20 xCD3 bispecific antibodies for large B cell lymphoma: latest updates from 2024 ASH annual meeting

IF 29.5 1区医学 Q1 HEMATOLOGY

Journal of Hematology & Oncology Pub Date : 2025-04-23 DOI:10.1186/s13045-025-01695-1

V. Tomarchio, L. Rigacci, O. Annibali

引用次数: 0

Abstract

Bispecific antibodies (BsAbs) represent an innovative class of off-the-shelf T-cell redirecting agents and are considered among the most promising immunotherapeutic strategies for the treatment of lymphoma. Notably, anti-CD20 × CD3 BsAbs have exhibited substantial monotherapy efficacy in patients with heavily pretreated B-cell non-Hodgkin lymphoma (B-NHL), showing a tolerable toxicity profile predominantly associated with T-cell activation-related side effects. In this study, we summarized several latest reports on CD20 × CD3 bsAbs for the therapy of Large B Cell Lymphoma (LBCL), also in first line, from the ASH 2024 annual meeting (ASH 2024).

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用于大B细胞淋巴瘤的CD20 xCD3双特异性抗体：来自2024年ASH年会上的最新消息

双特异性抗体（BsAbs）是一类创新的现成 T 细胞重定向制剂，被认为是治疗淋巴瘤最有前途的免疫疗法之一。值得注意的是，抗 CD20 × CD3 BsAbs 在重度预处理的 B 细胞非霍奇金淋巴瘤（B-NHL）患者中表现出了显著的单药疗效，并显示出主要与 T 细胞活化相关副作用有关的可耐受毒性特征。在本研究中，我们总结了 ASH 2024 年会（ASH 2024）上关于 CD20 × CD3 bsAbs 治疗大 B 细胞淋巴瘤（LBCL）（也是一线治疗）的几篇最新报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hematology & Oncology 医学-血液学

CiteScore

48.10

自引率

2.10%

发文量

169

审稿时长

6-12 weeks

期刊介绍： The Journal of Hematology & Oncology, an open-access journal, publishes high-quality research covering all aspects of hematology and oncology, including reviews and research highlights on "hot topics" by leading experts. Given the close relationship and rapid evolution of hematology and oncology, the journal aims to meet the demand for a dedicated platform for publishing discoveries from both fields. It serves as an international platform for sharing laboratory and clinical findings among laboratory scientists, physician scientists, hematologists, and oncologists in an open-access format. With a rapid turnaround time from submission to publication, the journal facilitates real-time sharing of knowledge and new successes.