Evaluation of Anti-Hyperlipidemic and Anti-Atherogenic Activity of Asiatic Acid and Its Effect on Lipid Peroxidation in Hyperlipidemic Rats

Abstract

Atherosclerosis is associated with several illnesses, such as coronary heart disease (CHD), peripheral vascular disease, and ischemic cerebrovascular disease. Atherosclerosis development and accompanying complications are predominantly influenced by Hyperlipidemia, which plays a crucial role. These illnesses are the primary cause of most sickness and death among those who are in their middle age or older. The incidence of dyslipidemia among Chinese adults aged 18 and older is 18.6%, indicating that there are around 160 million individuals affected by this condition. This represents the smallest number of patients globally. This analysis was derived from research undertaken in the field of epidemiology. Hence, developing a comprehensive approach for early prevention and treatment of Hyperlipidemia is imperative. The reason for this is that Hyperlipidemia has the potential to deteriorate progressively. Despite the notable progress made in treating Hyperlipidemia with synthetic drugs, there has been a renewed interest in medicinal plants and phytoconstituents known for their therapeutic capabilities. Asiatic acid, primarily present in Centella asiatica (L.), is classified as one of the phytocompounds that can decrease plasma lipids and lipid peroxidation. This plant may include asiaticoside, asiatic acid, and other components. Asiatic acid has the potential to prevent Hyperlipidemia. The aim of our research is to explore the anti-Hyperlipidemic and anti-atherosclerosis potential of Asiatic acid, which will help to explore its potential mechanism of action and a possibility of its usefulness in this regard.