Highly efficient antimicrobial coated surfaces with copolymers of guanylated-and natural product derived monomers

IF 4.3 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Chemistry and Physics Pub Date : 2025-04-23 DOI:10.1016/j.matchemphys.2025.130869

Mónica C.S. Fernandes , Rita Branco , P. Pereira , Jorge F.J. Coelho , Paula V. Morais , Arménio C. Serra

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Abstract

A series of copolymers mimicking antimicrobial peptides (AMPs) were synthesized by incorporating guanidine as the polar component and bio-based hydrophobic natural products such as thymol, menthol, tropolone, and β-citronellol as non-polar components. These copolymers were applied as antimicrobial coatings to glass surfaces pre-treated with a polyurethane-based waterborne varnish. The antimicrobial activity of the coatings was evaluated against Staphylococcus aureus (Gram-positive) and Escherichia coli strains (Gram-negative), and subsequently the most efficient coating was assessed for a Pseudomonas aeruginosa DSM1117 strain. Cytotoxicity tests with normal human dermal fibroblast (NHDF) cells were carried out to evaluate the cytocompatibility. The copolymer coatings (0.18 mg/cm²) showed excellent antimicrobial activity and minimal cytotoxicity, demonstrating their potential as effective antimicrobial materials for application on surface coatings.

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高效抗菌涂层表面与鸟苷化和天然产物衍生单体的共聚物

以胍为极性组分，百里香酚、薄荷醇、tropolone和β-香橼醇等生物基疏水天然产物为非极性组分，合成了一系列模拟抗菌肽的共聚物。这些共聚物作为抗菌涂层应用于用聚氨酯基水性清漆预处理的玻璃表面。测定了涂层对金黄色葡萄球菌（革兰氏阳性）和大肠杆菌（革兰氏阴性）的抑菌活性，并对铜绿假单胞菌DSM1117进行了抑菌效果评价。用正常人真皮成纤维细胞（NHDF）进行细胞毒性试验，评价其细胞相容性。该共聚物涂层（0.18 mg/cm2）具有优异的抗菌活性和最小的细胞毒性，显示了其作为表面涂层有效抗菌材料的潜力。

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来源期刊

Materials Chemistry and Physics 工程技术-材料科学：综合

CiteScore

8.70

自引率

4.30%

发文量

1515

审稿时长

69 days

期刊介绍： Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.