Understanding the structure of β2-glycoprotein I: new insights and future paths for antiphospholipid syndrome
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Abstract
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent life-threatening blood clots and pregnancy complications in individuals with antiphospholipid antibodies. Among these antibodies, those targeting the plasma glycoprotein β2-glycoprotein I (β2GPI) hold particular clinical significance. Despite extensive research, controversies persist regarding the structure of β2GPI, which has substantial implications for understanding autoantibody reactivity and APS development. This article critically examines recent advancements in the structural biology of β2GPI and its relevance to the recognition of antiphospholipid antibodies. Additionally, it introduces a new structure-based theory to explain how autoantibodies interact with β2GPI and the functional consequence of this interaction. Finally, it identifies potential areas for future research that could enhance approaches to diagnosing and treating APS.
了解β2-糖蛋白I的结构：抗磷脂综合征的新见解和未来途径
摘要抗磷脂综合征（APS）是一种自身免疫性疾病，以抗磷脂抗体患者复发性危及生命的血凝块和妊娠并发症为特征。其中以血浆糖蛋白β2-糖蛋白I （β2GPI）为靶点的抗体具有特殊的临床意义。尽管进行了广泛的研究，但关于β2GPI的结构仍存在争议，这对理解自身抗体反应性和APS的发展具有重大意义。本文批判性地研究了β2GPI结构生物学的最新进展及其与抗磷脂抗体识别的相关性。此外，它引入了一种新的基于结构的理论来解释自身抗体如何与β2GPI相互作用以及这种相互作用的功能后果。最后，它确定了未来研究的潜在领域，可以提高APS的诊断和治疗方法。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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