Recommended Clinical Context and Patient Context Data Elements for Liquid Biopsy Data Submitted to Data Repositories and Data Commons

IF 3.1 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Cts-Clinical and Translational Science Pub Date : 2025-04-22 DOI:10.1111/cts.70227

Robert L. Grossman, Jake Vinson, Elizabeth Bain, Karl Bisselou, Sanchi Chandan, Carolyn Compton, John Hu, Donald J. Johann, Frederick Jones, Gregory Jones, Suzanne LeBlang, Jerry S. H. Lee, Tara Lichtenberg, Christina M. Lockwood, John Lyle, Jean-Francois Martini, Jason D. Merker, Lauren Saunders, Howard Scher, Stella Somiari, Jenny You, Lauren C. Leiman

引用次数: 0

Abstract

In 2020, BLOODPAC recommended 11 pre-analytical minimal technical data elements for collection and submission of liquid biopsy data to public databases. This article expands on that work by recommending 22 clinical context and 10 patient context data elements. These elements, essential for liquid biopsy data submitted to repositories like the BLOODPAC Data Commons, cover tumor characteristics, disease progression, and patient demographics, supporting biomarker validation, research, and clinical trials.

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提交给数据存储库和数据共享的液体活检数据的推荐临床背景和患者背景数据元素

2020年，BLOODPAC推荐了11个分析前最小技术数据元素，用于收集和提交液体活检数据到公共数据库。本文通过推荐22个临床上下文和10个患者上下文数据元素来扩展这项工作。这些要素对于提交给BLOODPAC数据共享等存储库的液体活检数据至关重要，涵盖肿瘤特征、疾病进展和患者人口统计学，支持生物标志物验证、研究和临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cts-Clinical and Translational Science 医学-医学：研究与实验

CiteScore

6.70

自引率

2.60%

发文量

234

审稿时长

6-12 weeks

期刊介绍： Clinical and Translational Science (CTS), an official journal of the American Society for Clinical Pharmacology and Therapeutics, highlights original translational medicine research that helps bridge laboratory discoveries with the diagnosis and treatment of human disease. Translational medicine is a multi-faceted discipline with a focus on translational therapeutics. In a broad sense, translational medicine bridges across the discovery, development, regulation, and utilization spectrum. Research may appear as Full Articles, Brief Reports, Commentaries, Phase Forwards (clinical trials), Reviews, or Tutorials. CTS also includes invited didactic content that covers the connections between clinical pharmacology and translational medicine. Best-in-class methodologies and best practices are also welcomed as Tutorials. These additional features provide context for research articles and facilitate understanding for a wide array of individuals interested in clinical and translational science. CTS welcomes high quality, scientifically sound, original manuscripts focused on clinical pharmacology and translational science, including animal, in vitro, in silico, and clinical studies supporting the breadth of drug discovery, development, regulation and clinical use of both traditional drugs and innovative modalities.