Factors associated with inflammatory cytokines in family caregivers of allogeneic hematopoietic stem cell transplantation (HSCT) recipients

IF 8.8 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-04-10 DOI:10.1016/j.bbi.2025.04.013

Lena J. Lee, Jennifer J. Barb, Elisa H. Son, Li Yang, Chantal Gerrard, Gwenyth R. Wallen

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引用次数: 0

Abstract

Background

Family caregiving has been proposed as chronic stress that may lead to immune health risks through increased systemic inflammation. Cytokines are key modulators of inflammation via a complex network of interactions. However, most studies examined only a single to a few cytokines to determine whether they correlate with psychobehavioral variables of interest. This study aimed to investigate factors influencing multiple inflammatory cytokines in family caregivers of allogeneic hematopoietic stem cell transplantation (HSCT) recipients.

Methods

Baseline data from a randomized controlled clinical trial at the National Institutes of Health Clinical Center were collected from caregivers of allogeneic HSCT recipients. The 20 serum cytokine levels were measured using multiplexed cytokine immunoassays. Multiple linear regression was conducted.

Results

Caregivers (N = 45) were 44.6 ± 15.4 years of age; primarily female (87 %), White (66 %), non-Hispanic (82 %), and a spouse/partner of the HSCT recipient (56 %). Caring for HSCT recipients with hematologic malignancy predicted higher IL-12/IL-23p40 than caring for non-malignant HSCT recipients (β = 0.291, p = 0.044). Medication use was associated with higher IL-15 (β = 0.425, p = 0.017). Caregiver BMI overweight (β = 0.342, p = 0.043) or obese (β = 0.411, p = 0.010), taking prescribed medications (β = 0.521, p = 0.007), caregiving 8 to 16 h (β = 0.396, p = 0.027) or more than 16 h per day (β = 0.510, p = 0.006) predicted higher TNF-α than the counterparts.

Discussion

These findings suggest inflammatory responses may be associated with providing care to an HSCT recipient, especially in caregivers who take medications, provide more hours of care a day and care for patients with hematologic malignancies. The results highlight a physiological response of stress and bring to light the importance of developing interventions focused on reducing time spent caregiving, such as a respite care program for family caregivers.

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异基因造血干细胞移植（HSCT）受者的家庭照顾者中与炎症因子相关的因素

家庭照顾被认为是一种慢性压力，可能通过增加全身性炎症导致免疫健康风险。细胞因子是炎症的关键调节剂，通过一个复杂的相互作用网络。然而，大多数研究只检测了一种或几种细胞因子，以确定它们是否与感兴趣的心理行为变量相关。本研究旨在探讨异基因造血干细胞移植（HSCT）受者家庭照顾者多种炎症因子的影响因素。方法从美国国立卫生研究院临床中心的一项随机对照临床试验中收集同种异体造血干细胞移植受者的护理人员的基线数据。采用多重细胞因子免疫分析法测定20种血清细胞因子水平。进行多元线性回归。结果给药者45例，年龄44.6±15.4岁；主要是女性（87%），白人（66%），非西班牙裔（82%）和HSCT接受者的配偶/伴侣（56%）。与非恶性造血干细胞移植患者相比，患有恶性造血干细胞移植患者的IL-12/IL-23p40的预测值更高（β = 0.291, p = 0.044）。用药与IL-15升高相关（β = 0.425, p = 0.017）。护理人员BMI超重（β = 0.342, p = 0.043）或肥胖（β = 0.411, p = 0.010），服用处方药（β = 0.521, p = 0.007），每天护理8至16小时（β = 0.396, p = 0.027）或超过16小时（β = 0.510, p = 0.006）与同行相比，TNF-α升高。这些研究结果表明，炎症反应可能与对造血干细胞移植患者的护理有关，特别是那些服用药物、每天提供更多时间的护理和对血液系统恶性肿瘤患者的护理。研究结果强调了压力的生理反应，并揭示了开发干预措施的重要性，重点是减少花在照顾上的时间，比如家庭照顾者的临时护理计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.