Haytham Elgharably MD , Haley Jenkins MD , Davut Cekmecelioglu MD , Kamal S. Ayyat MD , Ahmed K. Awad MD , Patrick R. Vargo MD , Shinya Unai MD , Eric E. Roselli MD , Lars G. Svensson MD, PhD , Gosta B. Pettersson MD, PhD
{"title":"Are early outcomes of reoperative aortic root surgery impacted by previous root procedure and indication for reintervention?","authors":"Haytham Elgharably MD , Haley Jenkins MD , Davut Cekmecelioglu MD , Kamal S. Ayyat MD , Ahmed K. Awad MD , Patrick R. Vargo MD , Shinya Unai MD , Eric E. Roselli MD , Lars G. Svensson MD, PhD , Gosta B. Pettersson MD, PhD","doi":"10.1016/j.xjon.2025.02.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>Reoperative aortic root surgery after a previous root procedure is technically demanding, which can impact outcomes. Herein, we examined the impact of previous root procedure and operative indication on early outcomes.</div></div><div><h3>Methods</h3><div>From January 2010 to December 2022, 632 patients underwent reoperative aortic root surgery after previous root procedure (true redo root) at our institution. Baseline characteristics, operative details, and in-hospital complications were compared between groups on the basis of type of previous root prosthesis and infective endocarditis indication.</div></div><div><h3>Results</h3><div>In the whole cohort, the operative mortality was 2.2% and estimated survival was 93%, 80%, and 67% at 1, 5, and 10 years, respectively. Operative mortality was similar between previous homograft, Bentall, Freestyle, valve-sparing root reimplantation, and Ross (2%, 4%, 0%, 4%, and 0%, respectively, <em>P</em> = .4). Reoperations after Bentall and valve-sparing root reimplantation (prosthetic grafts) had greater rates of postoperative complications, such as reoperation for bleeding (15% and 8%, <em>P</em> = .01), delayed chest closure (18% and 8%, <em>P</em> = .02), and pacemaker insertion (13% and 12%, <em>P</em> = .03). Although there was no significant difference in operative mortality among patients with endocarditis versus those with other indications (3% vs 1%, <em>P</em> = .08), the postoperative course showed greater rates of reoperation for bleeding (19% vs 5%, <em>P</em> < .01) and prolonged ventilation (38% vs 18%, <em>P</em> < .01).</div></div><div><h3>Conclusions</h3><div>At experienced centers, aortic root reoperation (true redo root) can be performed with low operative mortality. Explant of prosthetic graft material and endocarditis are associated with more complicated postoperative course, without significantly increased operative mortality.</div></div>","PeriodicalId":74032,"journal":{"name":"JTCVS open","volume":"24 ","pages":"Pages 31-46"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JTCVS open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S266627362500052X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective
Reoperative aortic root surgery after a previous root procedure is technically demanding, which can impact outcomes. Herein, we examined the impact of previous root procedure and operative indication on early outcomes.
Methods
From January 2010 to December 2022, 632 patients underwent reoperative aortic root surgery after previous root procedure (true redo root) at our institution. Baseline characteristics, operative details, and in-hospital complications were compared between groups on the basis of type of previous root prosthesis and infective endocarditis indication.
Results
In the whole cohort, the operative mortality was 2.2% and estimated survival was 93%, 80%, and 67% at 1, 5, and 10 years, respectively. Operative mortality was similar between previous homograft, Bentall, Freestyle, valve-sparing root reimplantation, and Ross (2%, 4%, 0%, 4%, and 0%, respectively, P = .4). Reoperations after Bentall and valve-sparing root reimplantation (prosthetic grafts) had greater rates of postoperative complications, such as reoperation for bleeding (15% and 8%, P = .01), delayed chest closure (18% and 8%, P = .02), and pacemaker insertion (13% and 12%, P = .03). Although there was no significant difference in operative mortality among patients with endocarditis versus those with other indications (3% vs 1%, P = .08), the postoperative course showed greater rates of reoperation for bleeding (19% vs 5%, P < .01) and prolonged ventilation (38% vs 18%, P < .01).
Conclusions
At experienced centers, aortic root reoperation (true redo root) can be performed with low operative mortality. Explant of prosthetic graft material and endocarditis are associated with more complicated postoperative course, without significantly increased operative mortality.
目的:在先前的主动脉根手术后进行主动脉根手术在技术上要求很高,这可能会影响结果。在此,我们研究了以前的根管手术和手术指征对早期结果的影响。方法2010年1月至2022年12月,632例患者在既往主动脉根手术(真重根)后接受再手术主动脉根手术。基线特征、手术细节和住院并发症在既往根假体类型和感染性心内膜炎指征的基础上进行组间比较。结果在整个队列中,1年、5年和10年的手术死亡率为2.2%,估计生存率分别为93%、80%和67%。先前同种移植物、Bentall、Freestyle、保留瓣膜的根再植和Ross的手术死亡率相似(分别为2%、4%、0%、4%和0%,P = 0.4)。本特尔和保留瓣膜的根再植(假体移植物)术后再手术的并发症发生率更高,如出血再手术(15%和8%,P = 0.01),延迟胸闭合(18%和8%,P = 0.02)和植入起搏器(13%和12%,P = 0.03)。虽然心内膜炎患者与其他适应症患者的手术死亡率无显著差异(3% vs 1%, P = .08),但术后出血的再手术率更高(19% vs 5%, P <;.01)和延长通气时间(38% vs 18%, P <;. 01)。结论在经验丰富的中心,主动脉根部再手术(真重根)手术死亡率低。假体移植材料外植体和心内膜炎与术后更复杂的病程相关,但未显著增加手术死亡率。