Finding Rearrangements in the Cell-Free DNA Haystack

IF 10 1区医学 Q1 ONCOLOGY

Clinical Cancer Research Pub Date : 2025-04-16 DOI:10.1158/1078-0432.ccr-25-0432

Kurtis D. Davies

引用次数: 0

Abstract

Circulating tumor DNA (ctDNA) analysis is now a widely used diagnostic approach in the management of patients with solid tumors, including gene fusion-driven lung cancer. However, the accurate detection of genetic rearrangements in ctDNA presents considerable technical challenges. Consequently, studies that assess and compare methodologies for detection are vital.

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在无细胞DNA干草堆中发现重排

循环肿瘤DNA （ctDNA）分析现在是一种广泛应用于实体肿瘤患者管理的诊断方法，包括基因融合驱动的肺癌。然而，准确检测ctDNA中的基因重排提出了相当大的技术挑战。因此，评估和比较检测方法的研究至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Cancer Research 医学-肿瘤学

CiteScore

20.10

自引率

1.70%

发文量

1207

审稿时长

2.1 months

期刊介绍： Clinical Cancer Research is a journal focusing on groundbreaking research in cancer, specifically in the areas where the laboratory and the clinic intersect. Our primary interest lies in clinical trials that investigate novel treatments, accompanied by research on pharmacology, molecular alterations, and biomarkers that can predict response or resistance to these treatments. Furthermore, we prioritize laboratory and animal studies that explore new drugs and targeted agents with the potential to advance to clinical trials. We also encourage research on targetable mechanisms of cancer development, progression, and metastasis.