Ultrasensitive and Selective Nanomolar Detection of Aceclofenac Using Bi2O3/CeO2@ B-NQds-Modified Electrodes Through an Advanced Photoelectrocatalytic Approach

IF 2.7 4区化学 Q3 CHEMISTRY, PHYSICAL

Electrocatalysis Pub Date : 2025-02-04 DOI:10.1007/s12678-025-00935-9

Babu Shobana, Periakaruppan Prakash

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Abstract

Patients undergoing treatment with nonsteroidal anti-inflammatory drugs (NSAIDs), such as aceclofenac (ACF), primarily aimed at managing conditions like rheumatoid arthritis, face potential risks associated with overdosage, impacting organs like the kidney, liver, gastrointestinal tract, and blood cells. Hence, accurate quantification of ACF in real samples becomes paramount. In this investigation, we propose an innovative voltammetric approach for the determination of ACF in urine specimens. The working electrode employed herein consisted of a glassy carbon electrode (GCE) modified with boron nitride quantum dots doped bismuth cerium oxide nanocomposite (Bi₂O₃/CeO₂@B-NQds/GCE). Comprehensive characterization of the Bi₂O₃/CeO₂@B-NQds/GCE was conducted utilizing various techniques, followed by photoelectrochemical (PEC) analysis. These photosensors exhibited commendable sensitivity and reproducibility, and their preparation was deemed facile, rapid, and cost-effective. The impact of diverse interfering species was scrutinized, alongside calibration procedures to ascertain analytical performance. Remarkably, the results unveiled a high degree of linearity within the range of 0.6 to 13.8 µM, with exceptional values for the limit of detection 4.2 nM. Moreover, the constructed photoelectrode demonstrated stability and reproducibility, showcasing promising potential for reliable ACF detection in urine samples upon successful validation. In addition to its potential for clinical diagnostics, this novel light-assisted voltammetric technique holds promise for enhancing patient care by enabling precise monitoring of ACF levels in urine, facilitating personalized treatment regimens for individuals undergoing NSAID therapy. Furthermore, its ease of use and cost-effectiveness make it a practical tool for routine screening in medical settings, offering a valuable asset for healthcare professionals striving to optimize patient outcomes.

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来源期刊

Electrocatalysis CHEMISTRY, PHYSICAL-ELECTROCHEMISTRY

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： Electrocatalysis is cross-disciplinary in nature, and attracts the interest of chemists, physicists, biochemists, surface and materials scientists, and engineers. Electrocatalysis provides the unique international forum solely dedicated to the exchange of novel ideas in electrocatalysis for academic, government, and industrial researchers. Quick publication of new results, concepts, and inventions made involving Electrocatalysis stimulates scientific discoveries and breakthroughs, promotes the scientific and engineering concepts that are critical to the development of novel electrochemical technologies. Electrocatalysis publishes original submissions in the form of letters, research papers, review articles, book reviews, and educational papers. Letters are preliminary reports that communicate new and important findings. Regular research papers are complete reports of new results, and their analysis and discussion. Review articles critically and constructively examine development in areas of electrocatalysis that are of broad interest and importance. Educational papers discuss important concepts whose understanding is vital to advances in theoretical and experimental aspects of electrochemical reactions.