The crucial role of small heat shock proteins in prostate cancer: mechanisms and new therapeutic perspectives

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2025-04-11 DOI:10.1016/j.bbagrm.2025.195090

Yuankang Feng , Jialu Ma , Zhihao Bo , Dan Yue , Yong Wang

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Abstract

As resistance to new anti-androgen drugs occurs more frequently, increasing numbers of researchers are exploring alternative key molecular targets for prostate cancer treatment. The small heat shock protein (sHSP) family is a subclass of heat shock proteins (HSPs). Due to the smaller molecular size of their monomers, they often function as large oligomeric complexes with diverse biological roles, thus garnering increasing attention from urologists. Different members of the sHSP family exhibit distinct biological roles in prostate cancer, offering a new perspective for precision therapy. In this review, we summarize the specific roles of sHSP family members in prostate cancer and analyze their similarities and differences. Additionally, we discuss and review the drugs targeting various sHSPs in prostate cancer, providing new insights into the exploration and further application of sHSP-targeted therapies.

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小热休克蛋白在前列腺癌中的关键作用：机制和新的治疗前景

随着新型抗雄激素药物耐药性的频繁发生，越来越多的研究人员正在探索前列腺癌治疗的其他关键分子靶点。小热休克蛋白（sHSP）家族是热休克蛋白的一个亚类。由于其单体的分子尺寸较小，它们通常作为具有多种生物学作用的大型寡聚复合物发挥作用，因此越来越受到泌尿科医生的关注。sHSP家族的不同成员在前列腺癌中表现出不同的生物学作用，为精准治疗提供了新的视角。本文就sHSP家族成员在前列腺癌中的具体作用进行综述，并分析其异同点。此外，我们还讨论和回顾了针对各种shsp在前列腺癌中的药物，为shsp靶向治疗的探索和进一步应用提供了新的见解。

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来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.