A radiomics approach to distinguish Progressive Supranuclear Palsy Richardson's syndrome from other phenotypes starting from MR images

Abstract

Background and objective

Progressive Supranuclear Palsy (PSP) is an uncommon neurodegenerative disorder with different clinical onset, including Richardson's syndrome (PSP-RS) and other variant phenotypes (vPSP). Recognising the clinical progression of different phenotypes would enhance the accuracy of detection and treatment of PSP. The study goal was to identify radiomic biomarkers for distinguishing PSP phenotypes extracted from T1-weighted magnetic resonance images (MRI).

Methods

Forty PSP patients (20 PSP-RS and 20 vPSP) took part in the present work. Radiomic features were collected from 21 regions of interest (ROIs) mainly from frontal cortex, supratentorial white matter, basal nuclei, brainstem, cerebellum, 3rd and 4th ventricles. After features selection, three tree-based machine learning (ML) classifiers were implemented to classify PSP phenotypes.

Results

10 out of 21 ROIs performed best about sensitivity, specificity, accuracy and area under the receiver operating characteristic curve (AUCROC). Particularly, features extracted from the pons region obtained the best accuracy (0.92) and AUCROC (0.83) values while by using the other 10 ROIs, evaluation metrics range from 0.67 to 0.83. Eight features of the Gray Level Dependence Matrix were recurrently extracted for the 10 ROIs. Furthermore, by combining these ROIs, the results exceeded 0.83 in phenotypes classification and the selected areas were brain stem, pons, occipital white matter, precentral gyrus and thalamus regions.

Conclusions

Based on the achieved results, our proposed approach could represent a promising tool for distinguishing PSP-RS from vPSP.