Network analysis of extraintestinal manifestations and associated autoimmune disorders in Crohn’s disease and ulcerative colitis

IF 12.4 1区医学 Q1 HEALTH CARE SCIENCES & SERVICES

NPJ Digital Medicine Pub Date : 2025-04-15 DOI:10.1038/s41746-025-01504-6

Daniel C. Baumgart, C. Hing Cheng, Tian X. Du, Michael D. Parkes, Daniel C. Sadowski, Eytan Wine, Frank Hoentjen, Brendan P. Halloran, Aldo Montano-Loza, Sergio Zepeda-Gomez, Karen Wong, Farhad Peerani, Randolph Goebel, J. Ross Mitchell

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Abstract

We detect and interactively visualize occurrence, frequency, sequence, and clustering of extraintestinal manifestations (EIM) and associated immune disorders (AID) in 30,334 inflammatory bowel disease (IBD) patients (Crohn’s disease (CD) n = 15924, ulcerative colitis (UC) n = 11718, IBD unclassified, IBD-U n = 2692, 52% female, median age 40 years (IQR: 25)) with artificial intelligence (AI). 57% (CD > UC 60% vs. 54%, p < 0.00001) had one or more EIM and/or AID. Mental, musculoskeletal and genitourinary disorders were most frequently associated with IBD: 18% (CD vs. UC 19% vs. 16%, p < 0.00001), 17% (CD vs. UC 20% vs. 15%, p < 0.00001) and 11% (CD vs. UC 13% vs. 9%, p < 0.00001), respectively. AI detected 4 vs. 5 vs. 5 distinct EIM/AID communities with 420 vs. 396 vs. 467 nodes and 11,492 vs. 9116 vs. 16,807 edges (links) in CD vs. UC vs. IBD, respectively. Our newly developed interactive free web app shows previously unknown communities, relationships, and temporal patterns—the diseasome and interactome.

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克罗恩病和溃疡性结肠炎肠外表现及相关自身免疫性疾病的网络分析

我们使用人工智能（AI）检测30,334例炎症性肠病（IBD）患者（克罗恩病（CD） n = 15924，溃疡性结肠炎（UC） n = 11718， IBD未分类，IBD- un = 2692, 52%女性，中位年龄40岁（IQR: 25））的肠外表现（EIM）和相关免疫疾病（AID）的发生、频率、序列和聚类并交互可视化。57% （CD > UC 60% vs. 54%, p < 0.00001）有一个或多个EIM和/或AID。精神、肌肉骨骼和泌尿生殖系统疾病最常与IBD相关：分别为18% （CD vs UC 19% vs 16%, p < 0.00001）、17% （CD vs UC 20% vs 15%, p < 0.00001）和11% （CD vs UC 13% vs 9%, p < 0.00001）。AI在CD、UC和IBD中分别检测到4个、5个和5个不同的EIM/AID社区，分别有420个、396个和467个节点，11,492个、9116个和16,807个边（链接）。我们新开发的交互式免费web应用程序显示了以前未知的社区，关系和时间模式-疾病和相互作用组。

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来源期刊

NPJ Digital Medicine Multiple-

CiteScore

25.10

自引率

3.30%

发文量

170

审稿时长

15 weeks

期刊介绍： npj Digital Medicine is an online open-access journal that focuses on publishing peer-reviewed research in the field of digital medicine. The journal covers various aspects of digital medicine, including the application and implementation of digital and mobile technologies in clinical settings, virtual healthcare, and the use of artificial intelligence and informatics. The primary goal of the journal is to support innovation and the advancement of healthcare through the integration of new digital and mobile technologies. When determining if a manuscript is suitable for publication, the journal considers four important criteria: novelty, clinical relevance, scientific rigor, and digital innovation.