Biosynthesis of BiFeO3 for BiFeO3@Ag-S-CH2-COOH as the nanocatalyst for one-pot synthesis of 2, 3-dihydroquinazolin-4(1H)-ones and their anti-blood cancer activity

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Molecular Structure Pub Date : 2025-04-09 DOI:10.1016/j.molstruc.2025.142288

Shankar Pralhadrao Phulwale , Shivaji Devrao Waghmare , Akshay Pandurang Gurav , Krishna Chaitanya Gunturu , Shankar Poshatti Hangirgekar

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引用次数: 0

Abstract

In this research, BiFeO₃ nanoparticles were synthesized using an extract from the leaves of Abelmoschus esculentus L. Moreover a novel BiFeO₃@Ag-S-CH₂-COOH nanocatalyst was developed through biosynthesis of BiFeO₃ and successfully employed for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones. The BiFeO₃@Ag-S-CH₂-COOH nanocatalyst was characterized using Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) analysis, high-resolution transmission electron microscopy (HR-TEM), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), thermogravimetric analysis-differential thermal analysis (TGA-DTA), and X-ray photoelectron spectroscopy (XPS) techniques. The greener BiFeO₃@Ag-S-CH₂-COOH nanoparticles demonstrated remarkable catalytic efficiency in the production of 2,3-dihydroquinazolin-4(1H)-ones. These magnetic nanoparticles exhibited excellent catalytic efficiency, could be readily separated with an external magnet and maintained high reusability with minimal decline in activity. The structures of the synthesized 2,3-dihydroquinazolin-4(1H)-one derivatives were validated using FT-IR, ¹H and ¹³C nuclear magnetic resonance (NMR), and mass spectrometry. Furthermore, these compounds were assessed for their anticancer activity against the NALM-19 blood cancer cell line.

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BiFeO3的生物合成BiFeO3@Ag-S-CH2-COOH作为一锅合成2,3 -二氢喹唑啉-4(1H)-的纳米催化剂及其抗血癌活性

通过生物合成 BiFeO3，开发了一种新型 BiFeO3@Ag-S-CH2-COOH 纳米催化剂，并成功用于 2,3-二氢喹唑啉-4(1H)-酮的一锅合成。研究人员使用傅立叶变换红外光谱（FT-IR）、X 射线衍射（XRD）、Brunauer-Emmett-Teller（BET）分析、高分辨率透射电子显微镜（HR-TEM）对 BiFeO3@Ag-S-CH2-COOH 纳米催化剂进行了表征、场发射扫描电子显微镜 (FE-SEM)、能量色散 X 射线光谱 (EDX)、热重分析-差热分析 (TGA-DTA) 和 X 射线光电子能谱 (XPS) 技术。更环保的 BiFeO3@Ag-S-CH2-COOH 纳米颗粒在生产 2,3-二氢喹唑啉-4(1H)-酮的过程中表现出显著的催化效率。这些磁性纳米粒子表现出卓越的催化效率，可通过外部磁铁轻松分离，并可保持较高的重复利用率，且活性下降极小。合成的 2,3-二氢喹唑啉-4(1H)-酮衍生物的结构通过傅立叶变换红外光谱、1H 和 13C 核磁共振（NMR）以及质谱进行了验证。此外，还评估了这些化合物对 NALM-19 血癌细胞系的抗癌活性。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.