Sleep disorders in rheumatoid arthritis: Incidence, risk factors and association with dementia

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-04-11 DOI:10.1016/j.semarthrit.2025.152722

Roslin Jose George , Rakesh Kumar , Sara J Achenbach , Edward Lovering , Ryan J Lennon , John M Davis III , Diego Z. Carvalho , Cynthia S Crowson , Elena Myasoedova

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引用次数: 0

Abstract

Background/Objective

We aimed to examine the incidence of sleep disorders (SD) in individuals with rheumatoid arthritis (RA) vs. non-RA comparators, evaluate risk factors for SD, and assess the association between incident SD and dementia in RA.

Methods

This retrospective cohort study included residents aged ≥50 years within an 8-county region of Minnesota who first met the 1987 ACR criteria for RA in 1980–2014. Individuals with RA were matched 1:1 with non-RA individuals on age, sex, and calendar year of RA incidence. Data on SD, cardiovascular disease (CVD) risk factors, CVD and other comorbidities were collected from the medical records.

Results

Nine hundred thirteen individuals with RA and 913 non-RA comparators were included (mean age: 65 years, 65 % female in both cohorts). During the median follow-up of 10.4 years in RA and 11.0 years in non-RA cohort, SD developed in 234 and 206 individuals, respectively. RA patients experienced an increased risk for any incident SD (HR 1.34; 95 % CI:1.11–1.61) and insomnia (HR 1.34; 95 % CI:1.03–1.73). Obesity, dyslipidemia, presence of CVD, depression, anxiety, and more recent calendar year of RA incidence were associated with increased risk of any SD in RA. There were no significant association between SD overall and by subtype with dementia in RA.

Conclusion

Individuals with RA (vs non-RA) experienced a significantly increased risk for any SD, particularly insomnia. CVD and CVD risk factors, as well as depression and anxiety increased the risk for incident SD in RA. There was no significant association between SD and dementia in RA.

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类风湿关节炎的睡眠障碍：发病率、危险因素和与痴呆的关系

背景/目的本研究旨在研究类风湿关节炎（RA）患者与非类风湿关节炎患者的睡眠障碍（SD）发生率，评估睡眠障碍的危险因素，并评估类风湿关节炎患者睡眠障碍与痴呆之间的关系。方法本回顾性队列研究纳入明尼苏达州8个县地区年龄≥50岁的居民，这些居民在1980-2014年首次符合1987年RA的ACR标准。在年龄、性别和RA发病年份方面，RA患者与非RA患者的比例为1:1。从医疗记录中收集SD、心血管疾病（CVD）危险因素、CVD和其他合并症的数据。结果纳入913名RA患者和913名非RA对照者（平均年龄：65岁，两组中65%为女性）。在中位随访期间，RA组为10.4年，非RA组为11.0年，分别有234人和206人出现SD。RA患者发生任何突发SD的风险增加(HR 1.34；95% CI: 1.11-1.61)和失眠(HR 1.34；95% ci: 1.03-1.73)。肥胖、血脂异常、心血管疾病、抑郁、焦虑以及最近一年的RA发病率与RA中任何SD的风险增加相关。总体SD和亚型SD与RA痴呆之间无显著相关性。结论：类风湿性关节炎患者（与非类风湿性关节炎患者相比）发生任何SD的风险显著增加，尤其是失眠。心血管疾病和心血管疾病危险因素，以及抑郁和焦虑增加了类风湿性关节炎发生SD的风险。类风湿关节炎患者SD与痴呆无显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.