[BMIM]BF4-Mediated Multicomponent Synthesis of N-[(2-Hydroxynaphthalen-1-yl)(1H-pyrazol-5-yl)methyl]acetamides

Abstract

Naphthalene-bridged pyrazole scaffolds are important as fundamental components in numerous pharmacologically active novel chemical entities. The present study focuses on the synthesis of derivatives of N-((2-hydroxynaphthalen-1-yl)(1H-pyrazol-5-yl)methyl)acetamides (4). This synthesis was achieved through a one-pot three-component reaction involving naphthalen-2-ol (1), 1H-pyrazole-5-carbaldehydes (2), and acetamides (3). The reaction was conducted using [BMIM][BF₄] as a green reaction medium, producing good yields of the desired products. The compounds 4b, 4c, and 4d showed similar amino acid interaction with Thr 179 and docking scores of –7.839, –8.021, and –8.446 with 5LYJ.pdb. The compound 4f showed interaction with Tyr 281 and a docking score of –7.293 with 6WV3.pdb.