Editorial expression of concern: Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism

Abstract

Correction: Mol Cancer 13, 130 (2014)

https://doi.org/10.1186/1476-4598-13-130

The Editor-in-Chief is issuing an editorial expression of concern to alert readers that after the publication of this article, it was brought to the attention of the publisher that there are a number of image integrity concerns. There appear to be high similarities between Fig. 1e GAPDH and Fig. 3b GAPDH, representing different conditions. Figure 3d Invasion-BXPC-YY1 appears to partially overlap with Fig. 3d Migration-BXPC-Scramble shRNA. Figure 5a Erk1/2-Vector and Fig. 5a p-Erk1/2-YY1 shRNA also appear to be highly similar. The authors were able to provide the original cell images for Fig. 3d, but were unable to provide the original images for any of the blots. Readers are urged to take caution when interpreting the content and conclusions of this article.

Authors Jing-Jing Zhang. Yun-Peng Peng, Yi Miao, Kun-Ling Xie, and Yi Zhu agree with this Editorial Expression of Concern. All other authors have not responded to correspondence from the publisher regarding this Editorial Expression of Concern.

1. Zhang JJ, Zhu Y, Xie KL, et al. Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. Mol Cancer. 2014;13:130. https://doi.org/10.1186/1476-4598-13-130.

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Authors and Affiliations

1. Department of General Surgery, Jiangsu Province Academy of Clinical Medicine, Institute of Tumor Biology, The first Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China

   Jing-Jing Zhang, Yi Zhu, Ze-Kuan Xu, Cun-Cai Dai, Zhu-Yin Qian, Kui-Rong Jiang, Jun-Li Wu, Wen-Tao Gao, Qing Du & Yi Miao

2. Jiangsu Province Academy of Clinical Medicine, Institute of Tumor Biology, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China

   Jing-Jing Zhang, Yi Zhu, Ze-Kuan Xu, Qing Du & Yi Miao

3. The First School of Clinical Medicine, Nanjing Medical University, 140 Hanzhong Road, Nanjing, 210029, People’s Republic of China

   Kun-Ling Xie, Yun-Peng Peng, Jin-Qiu Tao, Jie Tang & Zheng Li

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1. Jing-Jing ZhangView author publications

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Corresponding author

Correspondence to Yi Miao.

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Zhang, JJ., Zhu, Y., Xie, KL. et al. Editorial expression of concern: Yin Yang-1 suppresses invasion and metastasis of pancreatic ductal adenocarcinoma by downregulating MMP10 in a MUC4/ErbB2/p38/MEF2C-dependent mechanism. Mol Cancer 24, 112 (2025). https://doi.org/10.1186/s12943-025-02326-6

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• Published: 14 April 2025

• DOI: https://doi.org/10.1186/s12943-025-02326-6

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