Neuroprotective Properties of Transition Metal Dichalcogenide Nanoflowers Alleviate Acute and Chronic Neurological Conditions Linked to Mitochondrial Dysfunction.

IF 4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biological Chemistry Pub Date : 2025-04-09 DOI:10.1016/j.jbc.2025.108498

Charles L Mitchell,Mikhail Matveyenka,Dmitry Kurouski

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引用次数: 0

Abstract

Mitochondrial dysfunction is an expected cause of etiology and progression in numerous human neurological pathologies, including stroke, Alzheimer's, and Parkinson's diseases. Therefore, a neuroprotective treatment is an urgent and unmet need. Transition metal dichalcogenide nanoflowers (TMD NFs) exhibit unique biological properties. However, neuroprotective properties of these nanomaterials remain poorly understood. In the current study, the biological effect of molybdenum disulfide (MoS2) and molybdenum diselenide (MoSe2) TMD NFs on neurons and astrocytes was investigated. It was found that both nanomaterials lowered reactive oxygen species (ROS) levels, reduced mitochondrial impairment, and increased mitochondrial biogenesis. Neuroprotective effects of both TMD NFs resulted from upregulation of the PGC-1α pathway, the biological system responsible for mitochondrial biogenesis. Furthermore, administration of TMD NFs to C. elegans extended lifespan of the nematodes. These results indicate that TMD NFs can be used as novel neuroprotective therapeutic agents against acute and chronic neurological condition linked to mitochondrial dysfunction.

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过渡金属二硫化物纳米花的神经保护特性缓解与线粒体功能障碍相关的急性和慢性神经系统疾病。

线粒体功能障碍是许多人类神经系统疾病的病因和进展的预期原因，包括中风、阿尔茨海默病和帕金森病。因此，神经保护治疗是一个迫切和未满足的需求。过渡金属二硫化物纳米花（TMD NFs）具有独特的生物学特性。然而，这些纳米材料的神经保护特性仍然知之甚少。本研究研究了二硫化钼（MoS2）和二硒化钼（MoSe2） TMD NFs对神经元和星形胶质细胞的生物学效应。结果发现，这两种纳米材料均降低了活性氧（ROS）水平，减少了线粒体损伤，并增加了线粒体生物发生。两种TMD NFs的神经保护作用源于PGC-1α通路的上调，PGC-1α通路是负责线粒体生物发生的生物系统。此外，给线虫注射TMD NFs可以延长线虫的寿命。这些结果表明，TMD NFs可以作为一种新的神经保护治疗剂，用于治疗与线粒体功能障碍相关的急慢性神经系统疾病。

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来源期刊

Journal of Biological Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry

自引率

4.20%

发文量

1233

期刊介绍： The Journal of Biological Chemistry welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology, neurobiology, epigenetics, computational biology, ’omics, and many more. The outcome of our focus on papers that contribute novel and important mechanistic insights, rather than on a particular topic area, is that JBC is truly a melting pot for scientists across disciplines. In addition, JBC welcomes papers that describe methods that will help scientists push their biochemical inquiries forward and resources that will be of use to the research community.