Effect of dose administration aids on adherence of self-administered medications: a systematic review

IF 1 Q4 PHARMACOLOGY & PHARMACY

Journal of Pharmacy Practice and Research Pub Date : 2025-01-28 DOI:10.1002/jppr.1962

Kanika Chaudhri BMedSci (Hons), MD, PhD, Sonali R. Gnanenthiran MBBS, PhD, FRACP, FCSANZ, Anastasia Williams BSci, Madeleine Kearney BMedSci, MPH, Richard O. Day MB BS (Hons), MD, FRACP, Anthony Rodgers MBChB, DPH, FAFPHM, PhD, FAHMS, GAICD, Emily R. Atkins BSci, PhD

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Abstract

Aim

Failure to self-administer a medication is the most common reason for non-adherence. Dose administration aids (DAAs) are a simple and common solution to improve unintentional non-adherence for oral tablets. They range from compartmentalised pill boxes and automated medication dispensing devices to blister packs. The aim of this systematic review was to summarise the current literature assessing the impact of DAAs on medication adherence.

Data sources

A search of MEDLINE, Embase, CINAHL, and the Cochrane Library was conducted from the beginning of each database until April 2023.

Study selection

A search strategy and keywords list were developed with a medical research librarian. Two reviewers independently screened studies and extracted data. The primary outcome was to assess the effects of DAAs on medication adherence. The secondary outcome was to evaluate the changes in any health outcomes documented. The study was reported in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) 2020 statement and registered with PROSPERO (Study registration: CRD42018096087).

Results

Twenty-two randomised controlled trials were included. Median adherence improved within the intervention groups for self-reported (95.5%, range: 88%–100% vs 84.5%, range: 83%–98%) and non-self-reported (88%, range: 54%–100% vs 70%, range: 83%–98%) adherence compared to usual care. However, self-reported adherence was higher in both intervention and control groups than non-self-reported adherence. Measured changes to health outcomes included cardiovascular outcomes, plasma levels, cure rates for malaria, hospital admissions, venous thromboembolism, and anaemia. Even though self-reported adherence levels were high, included studies did not report many statistically significant improvements in health outcomes with DAAs.

Conclusion

The use of DAAs can considerably improve medication adherence, with limited data suggesting positive effects on patient outcomes. Healthcare providers should consider the use of these aids as part of a comprehensive treatment plan for patients who struggle with medication adherence.

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来源期刊

Journal of Pharmacy Practice and Research Health Professions-Pharmacy

CiteScore

1.60

自引率

9.50%

发文量

期刊介绍： The purpose of this document is to describe the structure, function and operations of the Journal of Pharmacy Practice and Research, the official journal of the Society of Hospital Pharmacists of Australia (SHPA). It is owned, published by and copyrighted to SHPA. However, the Journal is to some extent unique within SHPA in that it ‘…has complete editorial freedom in terms of content and is not under the direction of the Society or its Council in such matters…’. This statement, originally based on a Role Statement for the Editor-in-Chief 1993, is also based on the definition of ‘editorial independence’ from the World Association of Medical Editors and adopted by the International Committee of Medical Journal Editors.