Integration of a lifestyle modification intervention for women with overweight and obesity in a gynecologic oncology practice

IF 4.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Gynecologic oncology Pub Date : 2025-04-12 DOI:10.1016/j.ygyno.2025.04.516

David H. Morris , Alison Kosmacki , Leah Tolby , Christine Marx , Jessica Vanderlan , David G. Mutch , Graham Colditz , Andrea R. Hagemann

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引用次数: 0

Abstract

Objective(s)

We aimed to assess the feasibility and effectiveness of a remotely delivered, group-based lifestyle modification intervention (LMI) for women with gynecologic cancer and overweight or obesity in a real-world clinic.

Methods

A six-month LMI was implemented in an outpatient gynecologic oncologic clinic for women with a body mass index (BMI) >25 kg/m². Participants were given a weight loss goal of ≥5 % initial body weight. Retrospective data were collected from patients enrolled in the intervention from September 2019 through February 2023. Feasibility of the LMI was assessed by the rate of enrollment and retention in the intervention. De-identified zip code data were collected to assess geographic proximity of participants to the clinic. Repeated measure analysis of variance (ANOVA) was performed to evaluate change in weight across the intervention.

Results

164 patients were referred to the LMI with 82 patients being enrolled during the study timeframe. The sample consisted primarily of white (68.3 %) women between the ages of 30 to 73 years old (median age of 57) with an initial median BMI of 41.41 kg/m². 74 % of enrolled patients completed the entire LMI. The LMI resulted in a mean loss of 4.19 kgs (p < .001), with 40.30 % of patients losing ≥5 % initial body weight.

Conclusions

Remotely delivered, group based LMI for gynecologic cancer patients with overweight or obesity is feasible in clinical practice and can transcend rural-urban inequalities. Patients in the LMI achieved statistically and clinically significant weight loss, comparable to that observed in more rigorous clinical trial.

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在妇科肿瘤学实践中对超重和肥胖妇女的生活方式改变干预的整合

我们的目的是评估在现实世界中针对患有妇科癌症且超重或肥胖的妇女开展的远程小组生活方式调整干预（LMI）的可行性和有效性。方法在妇科肿瘤门诊为体重指数（BMI）为 25 kg/m2 的妇女实施了为期 6 个月的 LMI。参与者的减重目标是初始体重≥5%。从 2019 年 9 月到 2023 年 2 月，对参加干预的患者进行了回顾性数据收集。根据干预的注册率和保留率评估 LMI 的可行性。收集了去身份化的邮政编码数据，以评估参与者与诊所的地理距离。进行了重复测量方差分析（ANOVA），以评估整个干预过程中体重的变化。样本主要由白人女性（68.3%）组成，年龄在 30 至 73 岁之间（中位数为 57 岁），初始体重指数中位数为 41.41 kg/m2。74% 的入组患者完成了整个 LMI。结论：针对超重或肥胖的妇科癌症患者开展的远程、集体 LMI 在临床实践中是可行的，而且可以消除城乡之间的不平等。参加 LMI 的患者在统计和临床上都取得了显著的体重减轻效果，与在更严格的临床试验中观察到的效果相当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic oncology 医学-妇产科学

CiteScore

8.60

自引率

6.40%

发文量

1062

审稿时长

37 days

期刊介绍： Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy