Biodegradation of per- and polyfluoroalkyl substances: microbes, enzymes and their interactions

IF 8.6 1区环境科学与生态学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Reviews in Environmental Science and Bio/Technology Pub Date : 2025-03-14 DOI:10.1007/s11157-025-09721-x

Dongyun Ye, Zeyu Wang, Xiaofei Qian, Kai Ouyang, Dizhi Wu, Fan Tang, Dzmitry Hrynsphan, Tatsiana Savitskaya, Jun Chen

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Abstract

Per- and polyfluoroalkyl substances (PFAS) are highly persistent organic pollutants due to their strong C–F bonds, which contribute to their environmental persistence and associated health risks. Naturally-occurring microbes have the ability to degrade PFAS, with Pseudomonas genus showing the highest efficiency, including Pseudomonas plecoglossicida (75%) and Pseudomonas aeruginosa (67%), which has received much attention. This review explores the underlying mechanisms during microbial PFAS degradation, emphasizing bond cleavage processes, including C–F and C–Cl bonds, and the critical roles of microbial enzymes. Microorganisms utilize specialized metabolic strategies to actively cleave chemical bonds within PFAS molecules, initiating their breakdown. Additionally, microorganisms secrete specific enzymes, which play pivotal roles in catalyzing PFAS degradation. Microorganisms and their enzymes can transform and/or defluorinate PFAS through different metabolic processes, improving the efficiency of PFAS degradation. This review further explores the current challenges in PFAS biodegradation and outlines future research directions, aiming to help future studies overcome these obstacles and drive progress in this field.

Graphical Abstract

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全氟烷基和多氟烷基物质的生物降解：微生物、酶及其相互作用

全氟烷基和多氟烷基物质是高度持久性的有机污染物，因为它们具有很强的碳-氟键，这有助于它们的环境持久性和相关的健康风险。天然存在的微生物具有降解PFAS的能力，其中以假单胞菌属的效率最高，其中plecoglossidida假单胞菌（75%）和铜绿假单胞菌（67%）的效率备受关注。本文探讨了微生物降解PFAS的潜在机制，重点介绍了键裂解过程，包括C-F键和C-Cl键，以及微生物酶的关键作用。微生物利用专门的代谢策略主动地切割PFAS分子内的化学键，启动它们的分解。此外，微生物分泌特定的酶，在催化PFAS降解中起关键作用。微生物及其酶可以通过不同的代谢过程转化和/或去氟化PFAS，从而提高PFAS的降解效率。本文进一步探讨了PFAS生物降解面临的挑战和未来的研究方向，旨在帮助未来的研究克服这些障碍，推动该领域的发展。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in Environmental Science and Bio/Technology Environmental Science-Waste Management and Disposal

CiteScore

25.00

自引率

1.40%

发文量

审稿时长

4.5 months

期刊介绍： Reviews in Environmental Science and Bio/Technology is a publication that offers easily comprehensible, reliable, and well-rounded perspectives and evaluations in the realm of environmental science and (bio)technology. It disseminates the most recent progressions and timely compilations of groundbreaking scientific discoveries, technological advancements, practical applications, policy developments, and societal concerns encompassing all facets of environmental science and (bio)technology. Furthermore, it tackles broader aspects beyond the natural sciences, incorporating subjects such as education, funding, policy-making, intellectual property, and societal influence.