The role of the tumor microenvironment and inflammatory pathways in driving drug resistance in gastric cancer: A systematic review and meta-analysis

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular basis of disease Pub Date : 2025-04-07 DOI:10.1016/j.bbadis.2025.167821

Francesco Albano , Francesca Lospinoso Severini , Giovanni Calice , Pietro Zoppoli , Geppino Falco , Tiziana Notarangelo

引用次数: 0

Abstract

Tumor microenvironment (TME) plays a pivotal role in progression and low responsiveness to chemotherapy of gastric cancer (GC). The cascade of events that culminate with a sustained and chronic activation of inflammatory pathways underlies gastric tumorigenesis. Infiltrating immune cells enrolling in crosstalk with cancer cells that regulate inflammatory and immune status, generating an immunosuppressive TME that influences the response to therapy. Here we discuss the role of TME and the activation of inflammatory pathways to comprehend strategies to improve drug response. Furthermore, we provides systematic insight the role of TME cytotypes and related signatures reinforcing the critical roles of TAMs and Tregs, in promoting GC chemoresistance and tumor progression.

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肿瘤微环境（TME）在胃癌（GC）的进展和化疗反应低下中起着关键作用。一连串的事件最终导致炎症通路的持续和慢性激活，这是胃癌发生的基础。浸润的免疫细胞与调节炎症和免疫状态的癌细胞发生串联，产生了影响治疗反应的免疫抑制TME。在此，我们讨论了TME的作用和炎症通路的激活，以理解改善药物反应的策略。此外，我们还系统地深入探讨了TME细胞型和相关特征在促进GC化疗耐药性和肿瘤进展中的作用，并强化了TAMs和Tregs的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochimica et biophysica acta. Molecular basis of disease 生物-生化与分子生物学

CiteScore

12.30

自引率

0.00%

发文量

218

审稿时长

32 days

期刊介绍： BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.