Neutral and positively charged indium(III) phthalocyanines: Comparative evaluation of the effect of light and ultrasound-assisted light stimulation on singlet oxygen production and DNA interaction analysis

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Polyhedron Pub Date : 2025-04-05 DOI:10.1016/j.poly.2025.117530

Öznur Dülger Kutlu

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Abstract

Nowadays, the development of sonophoto-activated phthalocyanine-based therapeutic agents and studies to determine their photochemical and sono-photochemical properties are very important in improving the success of the treatment of cancer with sonophotodynamic therapy (SPDT). Indium(III) phthalocyanines are among the most effective ones with their high singlet oxygen generation potential. Herein, a neutral indium(III) phthalocyanine (2) and its water-soluble cationic indium(III) phthalocyanine derivative (2a) were synthesized. The synthesized phthalocyanines were sonochemically, photochemically and sono-photochemically excited and the excitation method effect on singlet oxygen generation was systematically studied by a comprehensive analysis. The experimental measurements indicated that exceptionally high quantum yields were obtained following sono-photochemical investigations. In addition to photochemical and sono-photochemical studies, the interaction of 2a with deoxyribonucleic acid (DNA) was investigated. The DNA binding constant (K_b) for 2a is 1.66 × 10⁶ M⁻¹ and the quenching constant (Kq) is 8.18 × 10¹³ M⁻¹s⁻¹. The results indicate that these sensitizers may serve as potential candidate sensitizer molecules for application in advanced cancer therapies.

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中性和带正电荷的铟(III)酞菁：光刺激和超声波辅助光刺激对单线态氧生成和 DNA 相互作用分析影响的比较评估

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.