Striasteroids A–C, Three Hybrid Steroids with Neuraminidase Inhibitory Activities from a Marine-Derived Striaticonidium cinctum

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-02 DOI:10.1021/acs.orglett.5c0090110.1021/acs.orglett.5c00901

Chunmei Chen, Jian Cai, Chun Yang, Huaming Tao, Lan Tang, Yonghong Liu* and Xuefeng Zhou*,

引用次数: 0

Abstract

Three unprecedented hybrid steroids, striasteroids A–C (1–3), together with a known analogue (4), were isolated from the fungus Striaticonidium cinctum SCSIO41432. Their structures were identified through spectroscopic data, X-ray crystallography, and electronic circular dichroism calculations. Compounds 1 and 2, which feature a new 6/6/6/6/6/5 hexacyclic framework, are polyketide–steroid hybrids with an oxabicyclo[3.3.1]nonane-bridged system. Compound 3, characterized as the first naturally occurring adenine–steroid hybrid, exhibited the most potent inhibitory activity against neuraminidase with an IC₅₀ value of 6.15 ± 1.15 μM.

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三种具有神经氨酸酶抑制活性的杂交甾体（Striasteroids a - c）

从真菌Striaticonidium cinctum SCSIO41432中分离出三种前所未有的杂交类固醇striasteroids a - c（1-3）和一种已知的类似物(4)。通过光谱数据、x射线晶体学和电子圆二色性计算确定了它们的结构。化合物1和2具有新的6/6/6/6/6/5六环框架，是具有无氧双环[3.3.1]壬烷桥接体系的聚酮-类固醇杂化物。化合物3是第一个天然存在的腺嘌呤类固醇杂合体，对神经氨酸酶的抑制活性最强，IC50值为6.15±1.15 μM。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.