Evaluation of the effectiveness of human breast milk exosomes in experimental testicular torsion-detorsion injury model.

Cirugia y cirujanos Pub Date : 2025-01-01 DOI:10.24875/CIRU.23000462

Ünal T Öztürk, Hatice S Y Cömert, Gül Şalcı, Ahmet Alver, Sevdegül A Mungan, Neslihan Sağlam, Şeniz Erdem, Serdar Karakullukçu, Mustafa İmamoğlu, Haluk Sarıhan

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Abstract

Objective: Our aim was to examine the effectiveness of human breast milk exosomes in treating testicular torsion.

Methods: Rats were divided randomly into three equal groups. Group 1 was our control group. A torsion/detorsion model was created for the rats in Group 2. After the torsion/detorsion model, 1 mg/kg intraperitoneally human breast milk exosomes were given 30 min before detorsion in Group 3. All testicles were removed at the 6^th h of the experiment, for biochemical and histopathological examination.

Results: There was a statistically significant decrease in Group 3 MDA values compared to Group 2. When Group 3 and Group 2 SOD and CAT values were compared, it was seen that these values were higher in Group 3. Histopathologically a statistically significant difference was found in Group 3 compared to Group 1 and Group 2 in terms of ischemia/reperfusion injury.

Conclusion: We have shown that human breast milk exosomes in testicular torsion do not completely prevent reperfusion injury but significantly preserve testicular tissue.

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Cirugia y cirujanos

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