Rare Presentation of Rituximab-induced Interstitial Lung Disease in a Patient with Pemphigus Vulgaris.

Abstract

A 42-year-old female with a history of pemphigus vulgaris was started on rituximab after an inadequate response to corticosteroids. One month following the second cycle of rituximab, she developed acute interstitial pneumonia, which was linked to rituximab since a thorough workup revealed no evidence of an infectious cause. We initiated her on broad-spectrum intravenous (IV) antibiotics and antifungals, but the patient responded significantly to pulse methylprednisolone therapy.