Michael Ginevra, Linda J Dalic, Kristian Bulluss, Aaron E L Warren, John S Archer
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引用次数: 0
Abstract
A 19-year-old woman presented with drug-refractory epilepsy since age 7 years. She had bilateral tonic seizures, generalized paroxysmal fast activity, and trains of anteriorly predominant <2.5 Hz generalized spike-wave discharges, but no intellectual disability. Structural MRI demonstrated a solitary 1 cm nodule of subcortical heterotopia in the right frontal pole that had been felt to be unrelated because of the "generalized" field of epileptiform discharges. A sEEG study targeting the nodule and adjacent frontal lobe demonstrated almost continuous epileptiform discharges from the nodule with more than 60 electrographic seizures arising broadly from the frontal electrodes. Radiofrequency thermocoagulation to the nodule resulted in more than 3 years of seizure freedom. This case demonstrates that highly focal lesions can produce a generalized electroclinical phenotype.
期刊介绍：
Neurology, the official journal of the American Academy of Neurology, aspires to be the premier peer-reviewed journal for clinical neurology research. Its mission is to publish exceptional peer-reviewed original research articles, editorials, and reviews to improve patient care, education, clinical research, and professionalism in neurology.
As the leading clinical neurology journal worldwide, Neurology targets physicians specializing in nervous system diseases and conditions. It aims to advance the field by presenting new basic and clinical research that influences neurological practice. The journal is a leading source of cutting-edge, peer-reviewed information for the neurology community worldwide. Editorial content includes Research, Clinical/Scientific Notes, Views, Historical Neurology, NeuroImages, Humanities, Letters, and position papers from the American Academy of Neurology. The online version is considered the definitive version, encompassing all available content.
Neurology is indexed in prestigious databases such as MEDLINE/PubMed, Embase, Scopus, Biological Abstracts®, PsycINFO®, Current Contents®, Web of Science®, CrossRef, and Google Scholar.
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