Andjelika Milicic, Samuel Wilson, Shireen Javandel, Isabel Elaine Allen, Elena Tsoy, Lishomwa C Ndhlovu, Hannah Kibuuka, Michael Semwogerere, Rither Langat, Ibrahim Daud, Emmanuel Bahemana, Gloria David, Winnie Rehema, Iddah Ouma, Celine Ogari, Victor Anyebe, Zahra Parker, Hendrik Streeck, Christina S Polyak, Neha Shah, Julie A Ake, Victor Valcour
{"title":"Plasma Inflammatory Biomarkers Link to Worse Cognition Among Africans with HIV.","authors":"Andjelika Milicic, Samuel Wilson, Shireen Javandel, Isabel Elaine Allen, Elena Tsoy, Lishomwa C Ndhlovu, Hannah Kibuuka, Michael Semwogerere, Rither Langat, Ibrahim Daud, Emmanuel Bahemana, Gloria David, Winnie Rehema, Iddah Ouma, Celine Ogari, Victor Anyebe, Zahra Parker, Hendrik Streeck, Christina S Polyak, Neha Shah, Julie A Ake, Victor Valcour","doi":"10.1097/QAI.0000000000003679","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Despite broad access to antiretroviral therapy (ART) in sub-Saharan Africa (SSA), neurocognitive comorbidities remain common among people with HIV (PWH). Multiple lines of evidence link cognitive performance to inflammatory plasma biomarkers. This study examined this relationship within a robust sample in SSA.</p><p><strong>Methods: </strong>PWH and people without HIV (PWoH) aged 18 years or older, enrolled in the prospective African Cohort Study (AFRICOS) from 2013 to 2016 at multiple sites across Kenya, Nigeria, Tanzania, and Uganda, and underwent clinical evaluation. A neuropsychological battery assessed cognitive performance. Blood samples collected were analyzed by immunoassay. Using multivariable linear regression, we characterized associations between cognitive Z-scores and biomarker levels.</p><p><strong>Results: </strong>Participants included PWoH (17%, n=473), PWH with suppressed viremia (44%, n=1199) and PWH with unsuppressed viremia (exceeding 100 copies/mL, 39%, n=1065). Across groups, PWH with suppressed viremia were significantly older (means=37.1, 41.9 and 37.5, respectively, p<0.001). Among PWH, three biomarkers (CXCL10, CCL2, and sCD25) showed inverse relationships to cognitive performance on all measures (β=-0.163, β=-0.133, and β=-0.204, respectively, p<0.05). Inflammation did not relate to cognitive performance in PWoH. Examining individual neuropsychological test performance, the Grooved Pegboard, measuring psychomotor speed and manual dexterity, displayed the strongest associations with key biomarkers (CCL2 β=-0.252, sCD25 β=-0.293, and CXCL10 β=-0.214, p<0.01).</p><p><strong>Conclusion: </strong>In SSA, inflammatory markers associated with worse cognitive performance in both viremic and suppressed PWH.</p>","PeriodicalId":14588,"journal":{"name":"JAIDS Journal of Acquired Immune Deficiency Syndromes","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JAIDS Journal of Acquired Immune Deficiency Syndromes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/QAI.0000000000003679","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Despite broad access to antiretroviral therapy (ART) in sub-Saharan Africa (SSA), neurocognitive comorbidities remain common among people with HIV (PWH). Multiple lines of evidence link cognitive performance to inflammatory plasma biomarkers. This study examined this relationship within a robust sample in SSA.
Methods: PWH and people without HIV (PWoH) aged 18 years or older, enrolled in the prospective African Cohort Study (AFRICOS) from 2013 to 2016 at multiple sites across Kenya, Nigeria, Tanzania, and Uganda, and underwent clinical evaluation. A neuropsychological battery assessed cognitive performance. Blood samples collected were analyzed by immunoassay. Using multivariable linear regression, we characterized associations between cognitive Z-scores and biomarker levels.
Results: Participants included PWoH (17%, n=473), PWH with suppressed viremia (44%, n=1199) and PWH with unsuppressed viremia (exceeding 100 copies/mL, 39%, n=1065). Across groups, PWH with suppressed viremia were significantly older (means=37.1, 41.9 and 37.5, respectively, p<0.001). Among PWH, three biomarkers (CXCL10, CCL2, and sCD25) showed inverse relationships to cognitive performance on all measures (β=-0.163, β=-0.133, and β=-0.204, respectively, p<0.05). Inflammation did not relate to cognitive performance in PWoH. Examining individual neuropsychological test performance, the Grooved Pegboard, measuring psychomotor speed and manual dexterity, displayed the strongest associations with key biomarkers (CCL2 β=-0.252, sCD25 β=-0.293, and CXCL10 β=-0.214, p<0.01).
Conclusion: In SSA, inflammatory markers associated with worse cognitive performance in both viremic and suppressed PWH.
期刊介绍：
JAIDS: Journal of Acquired Immune Deficiency Syndromes seeks to end the HIV epidemic by presenting important new science across all disciplines that advance our understanding of the biology, treatment and prevention of HIV infection worldwide.
JAIDS: Journal of Acquired Immune Deficiency Syndromes is the trusted, interdisciplinary resource for HIV- and AIDS-related information with a strong focus on basic and translational science, clinical science, and epidemiology and prevention. Co-edited by the foremost leaders in clinical virology, molecular biology, and epidemiology, JAIDS publishes vital information on the advances in diagnosis and treatment of HIV infections, as well as the latest research in the development of therapeutics and vaccine approaches. This ground-breaking journal brings together rigorously peer-reviewed articles, reviews of current research, results of clinical trials, and epidemiologic reports from around the world.
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