Preclinical and clinical sex differences in the effects of alcohol on measures of brain dopamine: a systematic review.

IF 4.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Nathalie Barrios, Will Riordan, Vernon Garcia-Rivas, MacKenzie R Peltier, Walter Roberts, Terril L Verplaetse, Robert Kohler, Hang Zhou, Bubu A Banini, Sherry A McKee, Kelly P Cosgrove, Yasmin Zakiniaeiz
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Abstract

Introduction: Dopamine is involved in reward processing and plays a critical role in the development and progression of alcohol use disorder (AUD). However, little is known about the effect of sex on the relationship between dopamine and alcohol use/AUD. There is a critical need to identify the neurobiological mechanisms that contribute to sex differences in AUD to inform treatment approaches. This study aimed to review existing literature on sex differences in the effects of alcohol on brain dopamine measures in animals and individuals with heavy drinking/AUD.

Methods: A systematic review was conducted using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. PubMed was searched from inception to July 23rd, 2024.

Results: Of the 1,412 articles identified, 10 met study criteria (1 human, 9 animal), including in vivo (two positron emission tomography, four microdialysis) and ex vivo (two liquid chromatography, two fast-scan cyclic voltammetry) studies. Six studies included an alcohol challenge; three showed that females had greater alcohol-induced dopamine release than males in the ventral striatum and frontal cortex, while three showed no sex-related differences. Notably, the latter three studies examined sex in a combined AUD/control group or measured dopamine levels days after alcohol exposure. Two studies that examined the effects of prenatal alcohol exposure showed that prenatal-alcohol-exposed male offspring versus sex-matched air-exposed controls had greater prefrontal cortical dopamine D1 receptor availability, and prenatal-alcohol-exposed female offspring versus sex-matched air-exposed controls had greater striatal dopamine concentration. Two studies investigating the mu-opioid receptor (MOR) regulation of alcohol-induced dopamine release showed a faster decline in females relative to males while the other study found females may be less dependent on MOR activity at lower doses of alcohol relative to higher doses.

Conclusions: This systematic review showed mixed results regarding sex differences in brain dopamine measures in alcohol-exposed animals and individuals with AUD, which may arise from differences in the timing, quantity, and duration of alcohol exposure, species, conditions, models, and techniques. More research examining the effect of sex on the relationship between alcohol use and brain dopamine measures is needed to enhance our understanding of AUD development, progression, and treatment in both females and males.

酒精对脑多巴胺测量影响的临床前和临床性别差异:一项系统综述
多巴胺参与奖励加工,并在酒精使用障碍(AUD)的发生和发展中起关键作用。然而,关于性对多巴胺和酒精使用之间关系的影响知之甚少。目前迫切需要确定导致AUD性别差异的神经生物学机制,从而为治疗方法提供信息。本研究旨在回顾现有的关于酒精对重度饮酒动物和个体脑多巴胺测量影响的性别差异的文献。方法:采用首选报告项目进行系统评价和荟萃分析(PRISMA)指南。PubMed从成立到2024年7月23日被搜索。结果:在鉴定的1412篇文章中,10篇符合研究标准(1篇人,9篇动物),包括体内(2篇正电子发射断层扫描,4篇微透析)和体外(2篇液相色谱,2篇快速扫描循环伏安法)研究。六项研究包括酒精挑战;其中三项研究表明,女性在腹侧纹状体和额叶皮层释放的酒精诱导的多巴胺比男性多,而三项研究没有显示出与性别有关的差异。值得注意的是,后三项研究对AUD/对照组的性行为进行了调查,或测量了饮酒后几天的多巴胺水平。两项研究检测了产前酒精暴露的影响,结果表明,产前酒精暴露的雄性后代与性别匹配的空气暴露对照组相比,前额皮质多巴胺D1受体的可用性更高,而产前酒精暴露的雌性后代与性别匹配的空气暴露对照组相比,纹状体多巴胺浓度更高。两项研究调查了mu-阿片受体(MOR)对酒精诱导的多巴胺释放的调节,结果显示,女性的下降速度比男性快,而另一项研究发现,相对于高剂量的酒精,低剂量的酒精对女性MOR活性的依赖程度可能更低。结论:本系统综述显示,酒精暴露动物和AUD患者脑多巴胺测量的性别差异存在差异,这可能是由于酒精暴露的时间、数量和持续时间、种类、条件、模型和技术的差异。需要更多的研究来检验性别对酒精使用和脑多巴胺测量之间关系的影响,以增强我们对女性和男性AUD的发展、进展和治疗的理解。
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来源期刊
Biology of Sex Differences
Biology of Sex Differences ENDOCRINOLOGY & METABOLISM-GENETICS & HEREDITY
CiteScore
12.10
自引率
1.30%
发文量
69
审稿时长
14 weeks
期刊介绍: Biology of Sex Differences is a unique scientific journal focusing on sex differences in physiology, behavior, and disease from molecular to phenotypic levels, incorporating both basic and clinical research. The journal aims to enhance understanding of basic principles and facilitate the development of therapeutic and diagnostic tools specific to sex differences. As an open-access journal, it is the official publication of the Organization for the Study of Sex Differences and co-published by the Society for Women's Health Research. Topical areas include, but are not limited to sex differences in: genomics; the microbiome; epigenetics; molecular and cell biology; tissue biology; physiology; interaction of tissue systems, in any system including adipose, behavioral, cardiovascular, immune, muscular, neural, renal, and skeletal; clinical studies bearing on sex differences in disease or response to therapy.
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