Predictive factors for disseminated intravascular coagulation following colorectal perforation

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2025-04-04 DOI:10.1016/j.amjsurg.2025.116335

Toshimichi Kobayashi, Eiji Hidaka, Shoma Iida, Kanami Iwama, Takumi Seichi, Yoshihiro Nagae, Hiroyuki Higuchi, Itsuki Koganezawa, Masashi Nakagawa, Kei Yokozuka, Shigeto Ochiai, Takahiro Gunji, Toru Sano, Koichi Tomita, Satoshi Tabuchi, Naokazu Chiba, Shigeyuki Kawachi

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引用次数: 0

Abstract

Purpose

To determine the relationship between postoperative disseminated intravascular coagulation (DIC) and patient prognosis after surgery for colorectal perforation and to identify preoperative predictive factors for DIC.

Methods

We included 112 patients who underwent emergency surgery for colorectal perforation between April 2014 and September 2023. We performed a Kaplan–Meier analysis to assess 30-day postoperative survival with and without postoperative DIC, log-rank test to compare survival curves, and logistic regression analysis to identify preoperative predictive factors for postoperative DIC.

Results

The postoperative DIC and 30-day mortality rates were 37.5 % and 8 %, respectively. The 30-day postoperative mortality rates significantly differed between patients with postoperative DIC and those without (16.7 % vs. 2.9 %). The preoperative Sequential Organ Failure Assessment (SOFA) score was an independent predictive factor for postoperative DIC.

Conclusion

Evaluating preoperative SOFA scores may help assess postoperative DIC risk and enable early initiation of anticoagulant therapy in patients undergoing surgery for colorectal perforation.

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来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.