Methyltransferase-like 3-mediated RNA N⁶-methyladenosine contributes to immune dysregulation: diagnostic biomarker and therapeutic target.

IF 5.7 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI:10.3389/fimmu.2025.1523503

Deshuang Zhang, Ting Xu, Xiaoxue Gao, Yi Qu, Xiaojuan Su

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引用次数: 0

Abstract

Methyltransferase-like 3 (METTL3) plays a crucial role in post-transcriptional gene regulation. Substantial evidence links METTL3 to various immune dysfunctions, such as the suppression of antiviral immunity during viral infections and the disruption of immune tolerance in conditions like autoimmune diseases, myeloid leukemia, skin cancers, and anticancer immunotherapy. However, a thorough review and analysis of this evidence is currently missing, which limits the understanding of METTL3's mechanisms and significance in immune dysfunctions. This review aims to elucidate the roles and mechanisms of METTL3 in these immune issues, highlighting its connections and proposing new insights into its modulation of immune responses. Analysis results in this review suggest that METTL3 hampers antiviral immunity, worsens viral replication and infection, and disrupts immune tolerance; conversely, regulating METTL3 enhances antiviral immunity and facilitates viral clearance. Moreover, clinical data corroborates these findings, showing that METTL3 overexpression is associated with increased susceptibility to viral infections and autoimmune conditions. This review establishes a theoretical basis for considering METTL3 as a novel regulator, an important diagnostic biomarker, and a potential target for treating immune dysfunctions.

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甲基转移酶样3介导的RNA n6 -甲基腺苷有助于免疫失调：诊断生物标志物和治疗靶点。

甲基转移酶样3 （METTL3）在转录后基因调控中起着至关重要的作用。大量证据表明METTL3与各种免疫功能障碍有关，例如病毒感染期间抗病毒免疫的抑制以及自身免疫性疾病、髓性白血病、皮肤癌和抗癌免疫治疗等疾病的免疫耐受破坏。然而，目前缺乏对这些证据的全面回顾和分析，这限制了对METTL3在免疫功能障碍中的机制和意义的理解。本文旨在阐明METTL3在这些免疫问题中的作用和机制，强调其联系，并对其调节免疫反应提出新的见解。本综述的分析结果表明，METTL3阻碍抗病毒免疫，恶化病毒复制和感染，破坏免疫耐受；相反，调节METTL3可增强抗病毒免疫，促进病毒清除。此外，临床数据证实了这些发现，表明METTL3过表达与对病毒感染和自身免疫性疾病的易感性增加有关。本文综述为考虑METTL3作为一种新的调节因子、重要的诊断生物标志物和治疗免疫功能障碍的潜在靶点奠定了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.